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Abstract

The study evaluates the quality and consistency of various marketed brands of Amoxicillin capsules/tablets using UV spectroscopy. The objective is to determine the actual drug content in comparison to the labelled claim and assess any significant variability among the brands, which may influence therapeutic efficacy.

Keywords

Comparative Study, Different Brands, Amoxicillin, UV Spectroscopy

Introduction

Amoxicillin, a widely used β-lactam antibiotic, is available under numerous brand names. Despite regulatory standards, variations in drug content among brands can impact patient outcomes. UV spectrophotometry is a simple, cost-effective, and reliable method for quantifying drug content.                       

Fig: - Amoxicillin 250mg

Amoxicillin is available in the dosage form of Tablets, Capsules, Suspensions, Cream, Lotions, Ointments etc. & some combination brands.

List of Combination Brands of Amoxicillin: -

1.Amoxicillin + Clavulanic Acid Combination Brands: -

Brand Name

Formulation

Strength (Amox + Clav)

Manufacturer

Augmentin

Tablet

500 + 125 mg / 875 + 125 mg

GlaxoSmithKline (GSK)

Clavam

Tablet

500 + 125 mg / 625 mg

Alkem

Moxclav

Tablet

500 + 125 mg

Sun Pharma

Clavamox

Tablet / Capsule

250 + 125 mg / 500 + 125 mg

Pfizer

Curam

Tablet / Capsule

500 + 125 mg

Sandoz (Novartis)

Amoxyclav

Tablet

625 mg

Cipla

Duomox-CV

Tablet

500 + 125 mg

German Remedies

2. Amoxicillin + Clavulanic Acid (Clavulanate Potassium): -

  • Most common combination to overcome β-lactamase resistance.
  • Therapeutic Use: Broad-spectrum antibacterial.

Brand Name

Formulation

Strength (Amox + Clav)

Manufacturer

Augmentin

Tablet/Capsule

500 + 125 mg / 875 + 125 mg

GSK

Clavam

Tablet

500 + 125 mg / 625 mg

Alkem

Moxclav

Reference

  1. Indian Pharmacopoeia (IP), 2022.
  2. USP 43–NF 38, United States Pharmacopeia.
  3. Patel, A. et al. (2019). UV Spectrophotometric Estimation of Amoxicillin in Bulk and Dosage Form. IJPSR, 10(2), 880-884.
  4. Sharma, S. et al. (2020). Comparative Quality Evaluation of Marketed Brands of Antibiotics. Journal of Drug Delivery and Therapeutics, 10(5).
  5. WHO Guidelines on Quality Assurance of Pharmaceuticals (2021).

Photo
Shobha Sahu
Corresponding author

Rungta Institute of Pharmaceutical Sciences

Photo
Ayushi Khadatkar
Co-author

Rungta Institute of Pharmaceutical Sciences

Photo
Nitin Kurrey
Co-author

Rungta Institute of Pharmaceutical Sciences

Photo
Suman Sahu
Co-author

Rungta Institute of Pharmaceutical Sciences

Ayushi Khadatkar, Nitin Kurrey, Suman Sahu, Shobha Sahu*, Comparative Study of Different Brands of Amoxicillin Using UV Spectroscopy, Int. J. Sci. R. Tech., 2025, 2 (6), 382-385. https://doi.org/10.5281/zenodo.15632247

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