S. Tamil Alagan*
Ibuprofen is a widely used analgesic and anti-inflammatory drug, while omeprazole is a proton pump inhibitor commonly used to treat gastric acid-related disorders. The concurrent administration of these drugs is often required for patients with conditions such as gastric ulcers or pain associated with inflammatory disorders. However, their simultaneous use in a single dosage form presents challenges in terms of optimizing drug release profiles. This study aims to develop and evaluate a tablet-in-capsule drug delivery system for the simultaneous administration of ibuprofen and omeprazole, providing a convenient and effective solution for combination therapy. The main objective is to formulate a system that ensures optimal drug release, minimizes drug interactions, and improves patient compliance.
2. Drug Profile:
2.1 Ibuprofen:
Fig: 1 Structure of Ibuprofen
- IUPAC Name: 2[4-(2-methylpropyl) phenyl] propionic acid.
- Molecular Weight: 206.29g/mol
- Molecular Formula: C13H18O2
- MOA: Reversibly (cox-1andcox-2) propionic acid.
- Appearance: White crystalline powder.
- Odour: Characteristic odour.
- Solubility: Soluble in ethanol, Chloroform & Acetone and Insoluble in water.
- Routes: Oral, Rectal and topical intravenous
- Bioavailability: 49-73%.
- Protein binding: 92-99%.
- Metabolism: Hepatic (CYT2CS).
- Half-life: 1-4 hrs.
- Excretion: 48% Renal.
- Storage: To be stored at room temperature.
- Medicinal Uses: Analgesic, Antipyretic and for symptomatic relief of dysmenorrheal, Rheumatoid arthritis and oesteroarthritis, Rheumatic and non-rheumatic inflammatory disorder.
- Side Effects: Nausea, vomiting, dyspepsia, heart burn, diarrhoea, fluid retention, tinnitus, oedema, severe GI bleeding, ulceration, perforation, dizziness, skin irritation, anemia, apnea, respiratory infection, sepis and epigastritis.
- Contraindication: Active peptic ulcer, Hypersensitivity, Asthma, Renal or Hepatic disorder.
- Drug-Drug Interactions: Notable drug-drug interactions with the pharmacokinetics of ibuprofen include enhanced effect with monoclobemide, Increased risk of GI bleeding with warfarin, Reduces anti-platelet effect of aspirin, Increased risk of methotrexate and lithium toxicity.
- Omeprazole:
10.5281/zenodo.18092050