Abstract
Mouth ulcers, or aphthous ulcers, are common oral lesions that cause significant discomfort and can interfere with daily activities such as eating and speaking. This research focuses on the development and evaluation of herbal lozenges incorporating Neem (Azadirachta indica) and Tulsi (Ocimum sanctum) as primary active ingredients for the treatment of mouth ulcers. Neem is renowned for its potent anti-inflammatory, antimicrobial, and wound-healing properties, while Tulsi is valued for its analgesic and anti-inflammatory effects. The lozenges were formulated to dissolve slowly in the oral cavity, ensuring prolonged contact with ulcerated tissues, thereby maximizing therapeutic efficacy. Comprehensive evaluation included assessments of physicochemical properties, taste, texture, and stability, alongside in vitro studies to determine antimicrobial and healing potential. Results demonstrated that the synergistic combination of Neem and Tulsi in lozenge form provided effective pain relief, reduced inflammation, and promoted faster healing of mouth ulcers. The formulation was well-tolerated and exhibited favorable organoleptic properties. These findings suggest that herbal lozenges represent a promising, natural, and patient-friendly approach for the management of mouth ulcers, warranting further clinical investigation for widespread therapeutic use.
Keywords
Mouth ulcer, lozenges, Neem, Tulsi, herbal formulation, wound healing
Introduction
An open sore on the skin or mucous membrane, an ulcer is defined by the sloughing off of inflammatory dead tissue [1]. A superficial loss of tissue characterizes ulcers, which are sores on the skin's surface or a mucous membrane. Whilst they can occur practically anywhere, ulcers are most frequently found on the skin of the lower limbs and in the gastrointestinal system.
Mouth ulcer:
Aphous stomatitis, often known as mouth ulcer, is an inflammatory disease that affects the oral mucosa and is marked by recurrent oral and throat ulcers.9. About 20% of the general population is considered to be affected by this prevalent disease; in children, the estimated prevalence is 9%. (2).
Types of mouth ulcer:
- Minor aphthous ulcer:
About 80% of people with RAS have minor aphthous ulcers, which are the most prevalent kind of RAS. They occur every one to four months. Small (typically less than 5 mm in diameter), round or oval, and presenting as one to six ulcers at a time, these lesions are. A grey-white pseudo membrane covers the lesions and an erythematous halo encircles them. In [3] Mostly occurring in non-keratinized mucosa, such as the floor of the mouth, buccal, and labial mucosa (see Image: Aphthous Ulcer), minor RAS cures on its own in two weeks without leaving any scars. In [3] Phthous lesions may appear before oral pain.
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Vishakha Nagare
Corresponding author
Department of Pharmaceutics "Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha's Institute of Pharmaceutical Education and Research", Nashik – 422002, Maharashtra, India
Shubham Mahale
Co-author
Department of Pharmaceutics "Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha's Institute of Pharmaceutical Education and Research", Nashik – 422002, Maharashtra, India
Yash Shirsath
Co-author
Department of Pharmaceutics "Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha's Institute of Pharmaceutical Education and Research", Nashik – 422002, Maharashtra, India
Dr. Avinash Darekar
Co-author
Department of Pharmaceutics "Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha's Institute of Pharmaceutical Education and Research", Nashik – 422002, Maharashtra, India
Vishakha Nagare*, Shubham Mahale, Yash Shirsath, Dr. Avinash Darekar, Formulation and Evaluation of Herbal Lozenges for the Effective Management of Mouth Ulcers, Int. J. Sci. R. Tech., 2025, 2 (7), 75-82. https://doi.org/10.5281/zenodo.15801397
10.5281/zenodo.15801397
