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Wound healing is a multifaceted biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. The inflammatory phase, while essential for pathogen clearance and tissue repair, must be precisely regulated to prevent chronic inflammation and impaired healing. Medicinal herbs have long been used in traditional medicine for their wound-healing and anti-inflammatory properties. Many contain bioactive compounds such as flavonoids, alkaloids, saponins, and terpenoids that modulate key molecular pathways involved in inflammation and tissue regeneration. Notable herbs such as Centella asiatica, Curcuma longa (turmeric), Aloe vera, Calendula officinalis, and Chamomilla recutita have demonstrated efficacy in preclinical and clinical studies. Their mechanisms of action include inhibition of pro-inflammatory cytokines (e.g., TNF-?, IL-1?), enhancement of collagen synthesis, promotion of angiogenesis, and antioxidant activity. This review summarizes current findings on the phytochemistry, pharmacological actions, and therapeutic potential of selected anti-inflammatory herbs in wound healing. Diseases can be treated with medicinal herbs. Numerous illnesses, including rheumatoid arthritis, immune-mediated disorders, diabetes, heart attacks and more, can be classified as inflammatory. Among the plants discussed in this review are fenugreek, chamomile, ginger, ashwagandha, and turmeric. Since herbal medicine and lifestyle changes are used to alleviate inflammation, it is not a one-dimensional solution. Since the treatment of inflammation is not a single configuration relief, in this review article we tried to introduce to approach multidimensional medicinal access to treat inflammation, with the help of anti-inflammatory plants and by Modification our life style by exercise and diet. Vascular tissues intricate biological reaction to damaging stimuli like infections, damaged cells, or irritants includes inflammation. Redness, swollen joints, joint pain, stiffness and loss of joint function are some of its symptoms. The chemical diversity of natural goods makes them a great source for the development of new medications. The pharmaceutical management of inflammation by substances that vitally balance the inflammatory cascade is the primary topic of this review. Nevertheless, there isn’t a single agent that is specifically involved in wound healing that is sold in the healthcare industry. We will examine many agents or factors influencing inflammation in wound healing in this review.
Inflammation:Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals or microbiological agents1.Living tissue’s extreme reaction to any type of damage is inflammation. Pain, redness, heat or warmth, and swelling are the four main signs of inflammation. The arterioles in the surrounding tissue widen when any portion of the human body is injured. This results in increased blood flow to the region (redness)2. In order to repair tissue damage, wound healing involves a complex web of overlapping biological processes. Haemostasis, inflammation, tissue proliferation, and maturation are the main stages, and they involve a wide variety of cell types, some of which are local and others that are drawn in after an injury3.Herbal medicine is one of the most important medicines for treating all kinds of diseases. It is best therapy having least side effects and best Curative effects. In this review some plants which their anti-inflammatory effect has been thoroughly evaluated in many research articles and review articles which are of experimental based. Curcuma long, Zingiber officinale, Rosa Canina, cassia fistula, salvia officinale, Borago Officinale, Rosmarinus officinale, evening Primrose, Ribesnigrum, Oleaeuropea Herpagophytum, Elaeagnusangustifolia these are the plants which have strong anti-inflammatory activity and have been used for the of many inflammatory disorders such as in the treatment of rheumatoid arthritis, uveitis, Inflammatory bowel disease, ulcerative colitis, dermatitis, bronchitis, meningitis, sinusitis, periodontitis etc. In inflammatory process various mechanisms are involved4.
Symptoms:
?It is pain in muscles and joints.
?The person has fatigue.
?It was difficult to sleep.
?Depression and anxiety.
?There are Digestive problems.
?There are frequent infections.
Causes:
Typical causes include:
• Insufficient physical activity.
• Prolonged tension.
• Obesity is defined as having a BMI of 30 or higher, particularly if the additional weight includes visceral fat, which is found deep within the abdomen.
• Dysbiosis, or an imbalance between beneficial and detrimental microbes in your gut.
• Consistently consuming inflammatory foods, such as those high in trans-fat or salt
• Sleep and circadian rhythm disturbances.
• Toxin exposure, such as exposure to industrial chemicals, hazardous waste, and air pollution.
• Making use of tobacco products.
• Consistently consuming excessive amounts of alcohol.
Risk Factors of Inflammation:
Types of Inflammation
Reference
Burke, A., Smyth, E., & FitzGerald, G.A. Analgesic antipyretic agents; pharmacotherapy of gout. In L.B. Brunton, J.S. Lazo & K.L. Parker (Ed.) Goodman & Gilman's the Pharmacological Basis of Therapeutics (pp. 671-715). New York: McGraw-Hill. 2005
Nadkarni AK. Indian Materia Medica.Popular Press Bldg. 2000. www.ijapbc.com
Landen NX, Li Dongqing, Stahle M. Transition from inflammation to proliferation: acritical step during wound healing. Cell Mol Life Sci 2016;73(20):3861–85.www.elsevier.com/locate/jtv.
Chedea VS, Jisaka M. Inhibition of soybean lipooxygenases-structural and activity models for the lipooxygenaseisoenzymes family: recent trends for enhancing the diversity and quality of soybean products. In Tech., 2005; 6: 100–13. http://iamjournal.com
Akansha Shandarkar, Nikita Pawar, Arundhati kore, jagruti shelar, Anti-inflammatory Agents: A review on herbs that reduces inflammation, international journal of pharmaceutical sciences. Sci 2025, bol.3, issue 6. 444-401.https://wwwijpsjournal.com.
Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and biomarkers for wound healing. Plast Reconstr Surg 2016;138(Suppl. 3)18Se28S.
Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 2011; 17:113e25.
Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg 2017;43(Suppl. 1): S3e18
Lind Holm, C.; Searle, R. Wound management for the 21st century: Combining effectiveness and efficiency.Int. Wound J. 2016, 13, 5–15. [CrossRef]
Mustoe, T. Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy. Am. J. Surg. 2004, 187 (Suppl. 1), S65–S70. [CrossRef]
Widgerow, A.D.; King, K.; Tocco-Tussardi, I.; Banyard, D.A.; Chiang, R.; Awad, A.; Afzel, H.; Bhatnager, S.;9. Priyadarsini K.I. The chemistry of curcumin: From extraction to Therapeutic agent. Molecules. 2014; 19:20091-20112 https://doi.org/10.3390/molecules191220091
Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of Curcumin. Preclinical and clinical studies. Anticancer Research. 2003; 23(1/A):363-398
Rathore S, Mukim M, Curcumin: A Review for Health Benefits, International Journal of Research and Review 2020; 7(1).
Lestari M.L., Indrayanto G. Curcumin. Profiles Drug Subst. Excip. Relat. Methodol. 2014; 39:113-204. https://doi.org/10.1016/B978-0-12-800173-8.00003-9.
Gamage K, Dissanayake C, Angoda W, Waliwita LC, A Review on Medicinal Uses of Zingiber officinale (Ginger), International Journal of Health Sciences and Research, 2020; 10(6).
Potential health benefits and scientific review of ginger Najim A. Jabir Al-Awwadi College of Pharmacy, Thi-Qar University, Iraq. 2017; 9(7):111-116. https://doi.org/10.5897/JPP2017.0459
Https://draxe.com/Nutrition /anti-inflammatory herbs.
Rathod GB, Parmar P. Study of association of thrombocytopenia with plasmodium vivax infection. Indian J of Med Sciences, 2017; 69: 33-35.
Sahu A., Rawal N., Pangburn M. K. Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b. Biochemical Pharmacology, 1999; 57(12): 1439–1446. doi: 10.1016/s0006-2952(99)00044-1.
Amaral G. P., de Carvalho N. R., Barcelos R. P., et al. Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats. Food and Chemical Toxicology, 2013; 55: 48–55. doi: 10.1016/j.fct.2012.12.038.
Jucelia pizzetti Beninca, Julliana Bastos Dalmarlo, Moacir Geraldo pizzolatti, Tonia silvia frode, Analysis of the Anti-inflammatory properties of Rosrnorinus officinalis L. In mice. Food chemistry 124(2011) 468-475.www.elsevier-com//locate/food chem.
The culinary institute of America (2011). The professional chef(athed).Hobaken,new sersey : wiley.p, 180. ISBN.978-0-42 135-8
Rosemary, Drug.Com, 24 june.2024, Retrieved 22 march 2025.
Nair R, Sellaturay S, Sriprasad S. The history of ginseng in the management of erectile dysfunction in ancient China (3500–2600 BCE). Indian J Urol 2012;28:
Fenton WN. Lafitau, Joseph-François'. Dictionary of Canadian Biography, 3; 19741741–70.
Jia L, Zhao Y. Current evaluation of the millennium phytomedicine-ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr MedChem 2009; 16:2475.
Lee C, Wen J. Phylogeny of Panax using chloroplast trnC-trnD intergenic region and the utility of trnC–trnD in interspecific studies of plants. Mol Phylogenet Evol 2004; 31:894–903.
Kim KH, Lee D, Lee HL, Kim CE, Jung K, Kang KS. Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases:past findings and future directions. J Ginseng Res 2018; 42:239e47.
Wahid F, Khan T, Subhan F, Khan M, Kim Y. Ginseng pharmacology: multiple molecular targets and recent clinical trials. Drugs Future 2010; 35:399e407.
Shim JS, Song MY, Yim SV, Lee SE, Park KS. Global analysis of ginsenoside Rg1protective effects in beta-amyloid-treated neuronal cells. J Ginseng Res 2017; 41:566e71.
P. Pushpagadan & S.K. Tiwari, Peppermint handbook of herb & species, National Botanical Research institute,India, page no:460-478.
Abid aslam maon, Akmal nazir, Muhammad Kashif iqbal khan, Tabir ahmad, Rabia zia, murid, Muhammad Abrar, The therapeutic properties & applications of aloevera:a review journal of herbal medicine, Vol. 4,page no:1-39.
J. Hall, R. Bravo -clovzet, Anti-inflammatory Herbs for Arthritis, bioactive Food as Diatery Interventions for Arthritis & related Inflammatoty Disease, Chapter -46, https://dx.doi.org/10.1016/B978-0-12-397156-2-00253.2
Deepika Singh, prabir k. Chaudhari, A review on phytochemical & pharmacological properties of Holybasil, industrial crops & products.www. Elsevier.com/locate/incrop.
Vats, V., Yadav, S.P., Grover, J.K., 2004. Ethanolic extract of Ocimum sanctum leave partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J. Ethnopharmacol. 90, 155–160.
Maria. G. Goni, sara k. Roura, Alejandra. G. Ponce, Maria.R.Moreira, Clove (Syzygium aromaticum)oils, Essential oils in food preservation, flavor & safety, chapter -39, https://dx.doi.org/10.1016/B978+0-12-416641-7-000.39-0
Health Benefits of Cloves: Uses, Benefits & Side Effects https://share.google/TWhs5I58AHM5Gk90l
What is cardamom? Benefits and uses of cardamom spice, https://www.mastervlass.com/articles/what-is-cardamom-benefits-and-uses-of what-is-cardamom-benefits-and-uses-ofcardamom-spice#what-is-cardamom, Accessed: July 15, 2021.
10 Health Benefits of Cardamom, Backed by Science, https://www.healthline.com/nutrition/cardamom -benefits, Accessed: July 15, 2021.
A.C. Gonçalves, S. Castro, J. Paiva, C. Santos, P. Silveira, Taxonomic revision of the genus Calendula (Asteraceae) in the Iberian Peninsula and the Balearic Islands, Phytotaxa 352 (1) (2018) 1, https://doi.org/10.11646/ Phytotaxa.352.1.1.
Tutin TG, Heywood VH, Burges NA, Valentine DH, Walters SM, Webb DA (Eds.), Flora Europaea: Plantaginaceae to Compositae (and Rubiaceae), 4, Cambridge University Press, Cambridge, 1964, p. 207.
C. Ao, Comparative anatomy of bisexual and female florets, embryology in Calendula officinalis (Asteraceae), a naturalized horticultural plant, Sci. Hortic.114 (3) (2007) 214–219, https://doi.org/10.1016/j.scienta.2007.06.019
S.N.D. College of Pharmacy, Babhulgaon (Yeola), India (423401)
Gauri Paithankar
Co-author
S.N.D. College of Pharmacy, Babhulgaon (Yeola), India (423401)
Pooja Lasure
Co-author
S.N.D. College of Pharmacy, Babhulgaon (Yeola), India (423401)
Ramdas Darade
Co-author
S.N.D. College of Pharmacy, Babhulgaon (Yeola), India (423401)
Sakshi Gaikwad*, Vikram Sarukh, Gauri Paithankar, Pooja Lasure, Ramdas Darade, A Review of Anti-Inflammatory Herbs for Wound Healing: Traditional Knowledge and Insights Applications, Int. J. Sci. R. Tech., 2025, 2 (8), 147-165. https://doi.org/10.5281/zenodo.16811628
10.5281/zenodo.16811628
