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Abstract

Colophony, commonly known as rosin, is a natural resin derived from the oleoresin of pine trees and other coniferous plants. Historically, it has been valued for its adhesive, waterproofing, and protective properties, with early applications in shipbuilding, musical instruments, sealing wax, and traditional medicine. Extraction in the past relied on simple tapping and distillation methods, producing material of variable purity and limited industrial scope. In the present era, colophony has become a versatile industrial raw material, utilized in adhesives, varnishes, printing inks, soldering fluxes, pharmaceuticals, and cosmetics. Advances in extraction and refining techniques have improved quality and consistency, while chemical modifications such as hydrogenation, esterification, and polymerization have enhanced its performance in specialized applications. Its role in pharmaceuticals?as a coating agent, encapsulation material, and film former?has expanded due to its biocompatibility. However, allergenic potential in sensitive individuals remains a challenge. Future prospects for colophony are promising, driven by the need for renewable, biodegradable, and sustainable alternatives to petroleum-derived products. Green chemistry approaches, nanotechnology-based modifications, and development of hypoallergenic derivatives are expected to broaden its applications in advanced coatings, biomedical devices, and eco-friendly packaging. Thus, colophony remains a material of both historical significance and future potential.

Keywords

Colophony, rosin, resin acids, industrial applications, green chemistry, future prospects

Introduction

Colophony:

Colophony, also known as rosin, is a natural solid resin obtained from the oleoresin of pine trees (Pinus species). It is produced by distillation of crude turpentine, where the volatile fraction (turpentine oil) is removed, leaving behind the brittle, glassy solid known as colophony. It is widely used in pharmaceuticals, adhesives, varnishes, inks, and biomedical applications due to its adhesive, film-forming, and emulsifying properties. 1

Reference

  1. Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (Eds.). (2009). Handbook of Pharmaceutical Excipients. Pharmaceutical Press.
  2. Allen, N. S., Edge, M., Ortega, A., Liauw, C. M., Stratton, J., & McIntyre, R. B. (2011). Colophony-based resins: Chemistry, technology and applications. Polymer Degradation and Stability, 96(9), 1681–1691.
  3. Basketter, D. A., White, I. R., McFadden, J. P., & Kimber, I. (2003). Rosin (colophony): a review. Contact Dermatitis, 48(2), 63–67.
  4. Coppen, J. J. W., & Hone, G. A. (1995). Gum naval stores: Turpentine and rosin from pine resin. FAO Forestry Paper 80. Rome: FAO.
  5. Martín, C., Martín, S., García, A., & Alfaro, M. J. (2020). Rosin and rosin derivatives: Renewable materials for eco-friendly applications. Industrial Crops and Products, 155, 112823.
  6. Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2012). Handbook of Pharmaceutical Excipients (6th ed.). Pharmaceutical Press.
  7. Zinkel, D. F., & Russell, J. (1989). Naval Stores: Production, Chemistry, Utilization. Pulp Chemicals Association.
  8. Jain R, et al. Colophony: A versatile excipient for drug delivery. Int J Pharm Sci Rev Res. 2021.
  9. Ekundayo E. Natural resins and their pharmaceutical applications. J Pharm Bioallied Sci. 2019.
  10. Rowe RC, Sheskey PJ, Quinn ME (Eds.). Handbook of Pharmaceutical Excipients, 6th ed. Pharmaceutical Press, 2009.
  11. PubMed: Use of rosin and derivatives in drug delivery
  12. Drugs.com: Inactive ingredient – Colophony
  13. Aqil, M., Sultana, Y., & Ali, A. (2004). Matrix type transdermal drug delivery systems of metoprolol tartrate: In vitro characterization. Acta Pharmaceutica, 54(1), 63–70.
  14. Kumar, V., & Sharma, A. (2012). Role of natural resins in transdermal drug delivery systems. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3), 1–6.
  15. Thakur, R. R. S., & Price, R. D. (2009). Current trends in transdermal drug delivery systems: Adhesion and bioavailability. International Journal of Pharmaceutics, 371(1-2), 1–6.
  16. Sharma, N., & Agarwal, G. (2011). Role of natural polymers in transdermal drug delivery system. International Journal of Research in Pharmacy and Chemistry, 1(4), 1139–1144.
  17. U.S. Patent No. 5,656,286. (1997). Pressure-sensitive adhesive compositions using rosin esters.
  18. Feng, J., Wang, X., & Guo, Z. (2013). Rosin-based chemicals and polymers: Recent advances in synthesis and applications. Progress in Polymer Science, 38(8), 1132–1165. https://doi.org/10.1016/j.progpolymsci.2013.04.002
  19. Gandini, A. (2008). Polymers from renewable resources: a challenge for the future of macromolecular materials. Macromolecules, 41(24), 9491–9504.
  20. Isikgor, F. H., & Becer, C. R. (2015). Lignocellulosic biomass: a sustainable platform for the production of bio-based chemicals and polymers. Polymer Chemistry, 6(25), 4497–4559.
  21. Liu, J., & Chen, Y. (2014). Rosin-derived polymers and their biomedical applications. Journal of Applied Polymer Science, 131(4), 39872.
  22. Zhang, C., Ding, K., & Xu, J. (2017). Rosin-based polymers for sustainable applications. Green Chemistry, 19(12), 2771–2787.
  23. Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 6th Edition. Pharmaceutical Press; 2009.
  24. Banker GS, Rhodes CT. Modern Pharmaceutics. 4th Edition. Marcel Dekker; 2002.
  25. Ghosh TK, Jasti BR. Theory and Practice of Contemporary Pharmaceutics. CRC Press; 2005.
  26. Pachuau L, Das SC. "Colophony and its applications in drug delivery systems." Journal of Applied Pharmaceutical Science, 2017; 7(10): 227–232.
  27. Jyothi NVN, Prasanna PM, Sakarkar SN, Prabha KS, Ramaiah PS, Srawan GY. "Microencapsulation techniques, factors influencing encapsulation efficiency." Journal of Microencapsulation. 2010; 27(3): 187–197.
  28. Tadros T. Emulsion Formation and Stability. Wiley-VCH; 2013.
  29. Shukla RK, Tiwari A. "A review on role of natural resins in drug delivery." Int. J. Pharm. Sci. Rev. Res. 2012; 12(1): 85–90.
  30. Karlberg AT, Magnusson K, Nilsson U. "Colophony revisited." Contact Dermatitis. 1997; 36(1): 1–6.
  31. Dragland IS, Senning A, Borchgrevink CF. "The effect of rosin ointment on chronic wounds." Scandinavian Journal of Caring Sciences. 2011; 25(2): 341–347.
  32. Allen, L. V., Popovich, N. G., & Ansel, H. C. (2013). Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems (10th ed.). Lippincott Williams & Wilkins.
  33. Uddin, M. S., Sarker, M. Z. I., Ferdosh, S., Akanda, M. J. H., & Easmin, S. (2011). Pharmaceutical and biomedical applications of natural resins: A review. Journal of Pharmaceutical Sciences and Research, 3(6), 1427–1433.
  34. Rutuja V. shelke, Vikram S. Sarukh Int. J. Sci. R. Tech., 2024 1(11) "Wound Healing Pathways and Treatment: A Comprehensive Review.

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Rushikesh Sanap
Corresponding author

SND College of Pharmacy, Babhulgaon (Yeola), India (423401)

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Sarukh Vikram
Co-author

SND College of Pharmacy, Babhulgaon (Yeola), India (423401)

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Pund Sonali
Co-author

SND College of Pharmacy, Babhulgaon (Yeola), India (423401)

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Bhad Manoj
Co-author

SND College of Pharmacy, Babhulgaon (Yeola), India (423401)

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Araj Ishwar
Co-author

SND College of Pharmacy, Babhulgaon (Yeola), India (423401)

Rushikesh Sanap*, Saruk Vikram, Pund Sonali, Bhad Manoj, Araj Ishwar, A Review on Role of Colophony in Different Formulation, Int. J. Sci. R. Tech., 2025, 2 (9), 50-58. https://doi.org/10.5281/zenodo.17084883

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