Oral and injectable forms of Ondansetron HCl, though effective, often necessitate multiple dosing and are associated with gastrointestinal or parenteral drawbacks. Transdermal systems can bypass hepatic first-pass metabolism and offer steady plasma drug levels. The development of patches involves multiple formulation variables, including drug-polymer interactions, release enhancers, and matrix design.
Transdermal Patch
Transdermal patches represent a sophisticated drug delivery system that administers drug through the skin, ensuring controlled and sustained release into systemic circulation. They are part of the broader category known as Transdermal Drug Delivery Systems (TDDS).
- Key features include:
- Non-invasive: Avoids the gastrointestinal tract and first-pass hepatic metabolism.
- Controlled Release: Provides sustained or controlled drug delivery over hours or days.
- Improved patient compliance: especially advantageous for chronic conditions.
- Basic components of a transdermal patch are:
Bhawna Sirohi*
Hema Negi
10.5281/zenodo.15722037