Sandip Bhogal* 1
Vishal Madankar 2
Sohel Shaikh 1
Anil Panchal 3
Moringa oleifera is a medicinal plant that has gained a lot of interest for its diverse biological properties. Reviewed evidence indicates the biological capabilities of this plant expand to protecting against complications linked with heart disease, cancer, fatty liver, and diabetes mellitus1. For example, a previously published review supported the beneficial effects of the leaves of the Moringa oleifera in improving blood glucose control in experimental models of diabetes. Notably, this review indicated draw backs such as the limited number of studies that have reported on the potential beneficial effects of this plant, including the fact that summarized literature was mainly conducted in animals, through in vitro and in vivo preclinical models2. Nevertheless, while such information already affirms the hypoglycaemic potential of this medicinal plant, data regarding the prominent biochemical mechanisms implicated in the antidiabetic effects of Moringa oleifera have not been critically reviewed. Recently, Louisa and others supported the potential benefits of Moringa oleifera in cardiovascular or metabolic disorders, mainly by ameliorating the undesired pro-inflammatory response and inhibiting oxidative stress by mediating molecular mechanisms such as hindering nuclear factor kappa B (NF-κB) translocation or enhancing the antioxidant response of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) in different preclinical models3. Thus, there is a need to better understand such intracellular responses of Moringa oleifera within a setting of diabetes or in related metabolic complications. The current study provides a brief overview on Moringa oleifera as medicinal plant, followed by its therapeutic mechanisms in controlling diverse diabetic complications4.
Drug Profile:
- Biological Source: Moringa oleifera
- Family: Moringaceae
- Common Names: Drumstick tree, horseradish tree
- Origin: Is native to India, Arabia, and the East Indies. It is now widely cultivated in tropical and subtropical regions of the world5.
10.5281/zenodo.15315163