Marine Pharmacognosy

Abstract

Marine pharmacognosy, a specialized branch of pharmacognosy, investigates bioactive natural compounds derived from marine organisms. Covering nearly 70% of the Earth’s surface, marine ecosystems are an unparalleled source of structurally unique secondary metabolites with potential therapeutic value. Marine species such as sponges, tunicates, mollusks, cnidarians, algae, and marine microorganisms produce diverse bioactive molecules as ecological adaptations to extreme environments. These compounds exhibit potent pharmacological activities, including anticancer, antimicrobial, antiviral, anti-inflammatory, and antioxidant effects. Advances in analytical chemistry, genomics, and biotechnology have accelerated the discovery and development of marine-derived pharmaceuticals. This article reviews marine biodiversity, classification of marine bioactive compounds, pharmacological activities, approved marine drugs, and the challenges and prospects in marine pharmacognosy.

Keywords

Marine pharmacognosy, bioactive metabolites, marine biotechnology, drug discovery, marine biodiversity

Introduction

These examples highlight the ocean’s remarkable contribution to modern pharmacotherapy.

6. Challenges and Limitations

Dimmense potential, marine pharmacognosy faces several challenges:

1. Sustainable Supply: Harvesting marine organisms poses ecological and ethical issues.
2. Complex Chemical Structures: Synthesis and scale-up remain difficult and costly.
3. Ecological Impact: Overexploitation threatens marine biodiversity.
4. Legal and Bioprospecting Barriers: International regulations (e.g., Nagoya Protocol) complicate access to marine resources (Arrieta et al., 2021).

7. Morden Extraction and Analytical Challenges

Innovative extraction and analytical tools have improved the efficiency of marine compound discovery:

• Supercritical Fluid Extraction (SFE)
• Microwave-Assisted Extraction (MAE)
• High-Performance Liquid Chromatography (HPLC)
• LC-MS/MS and NMR Spectroscopy
• Metagenomics and Genome Mining

These technologies allow researchers to identify and characterize metabolites from even uncultivable marine microorganisms.

8. Genomics and Pharmacogenomics in Marine Drug Discovery

Genomics enables the identification of biosynthetic gene clusters responsible for natural product synthesis. Metagenomic sequencing and CRISPR-based editing facilitate heterologous expression of marine genes in laboratory strains. Pharmacogenomics further aids in tailoring marine-derived drugs to individual genetic profiles, improving efficacy and minimizing side effects (Kumar et al., 2023).

9. Future Prospects

The integration of marine biotechnology, synthetic biology, and AI-driven screening is revolutionizing marine drug discovery. Marine microbiomes and symbiotic bacteria remain underexplored resources. Collaborative global initiatives focusing on sustainable blue bioprospecting promise to expand the marine pharmacognosy landscape.

Advantages and Disadvantages of Marine Pharmacognosy

Marine pharmacognosy offers numerous scientific, economic, and medical benefits that make it a promising field for future drug discovery and development.

1. Vast Biodiversity and Chemical Novelty

The marine ecosystem covers approximately 70% of the Earth’s surface and contains an immense diversity of life forms—sponges, tunicates, algae, mollusks, cnidarians, and marine microbes. These organisms produce unique and structurally complex secondary metabolites not found in terrestrial species, providing an unparalleled chemical library for drug discovery (Blunt et al., 2022).

2. New Lead Compounds for Drug Development

Marine organisms have yielded several clinically valuable drugs, such as Cytarabine, Trabectedin, and Eribulin, which have been successfully developed for cancer treatment. Such discoveries highlight the marine environment’s potential to produce lead compounds with novel mechanisms of action (Hu et al., 2020).

3. High Potency and Specificity

Marine natural products often exhibit high biological potency and target specificity due to the evolutionary adaptation of marine species to extreme environmental pressures. These compounds may serve as templates for highly effective pharmaceuticals (Martins et al., 2019).

4. Potential in Multiple Therapeutic Areas

Marine metabolites have shown broad pharmacological activities including anticancer, antimicrobial, antiviral, anti-inflammatory, antioxidant, and neuroprotective properties, expanding their applicability across diverse therapeutic fields (Pereira et al., 2020).

5. Opportunities for Biotechnological Innovation

The integration of marine biotechnology and genomics enables sustainable production of bioactive compounds through microbial fermentation and genetic engineering, reducing the dependence on wild harvesting (Kumar et al., 2023).

6. Economic and Industrial Potential

Marine pharmacognosy not only contributes to the pharmaceutical sector but also benefits nutraceuticals, cosmetics, and bioenergy industries. Marine-derived ingredients are increasingly valued in global markets for their bioactivity and eco-friendly appeal (Martins et al., 2019).

Disadvantages

Despite its vast promise, marine pharmacognosy also faces significant scientific, environmental, and regulatory challenges.

1. Difficulty in Sustainable Collection

Many marine organisms live in inaccessible deep-sea environments, making large-scale collection difficult, expensive, and ecologically risky. Overharvesting may disrupt marine ecosystems and biodiversity (Arrieta et al., 2021)

2. Complexity in Chemical Isolation and Characterization

Marine natural products often exist in minute quantities and are chemically unstable. Their extraction, purification, and structural elucidation require sophisticated and costly technologies such as LC-MS, NMR, and chromatography (Hu et al., 2020)

3. Limited Reproducibility and Supply Issues

Seasonal variations, habitat specificity, and low biomass yield make it difficult to obtain consistent supplies of bioactive compounds, posing challenges for preclinical and commercial development.

4. High Research and Development Cost

The transition from discovery to clinical drug approval involves long, complex, and costly processes. Marine-derived compounds may require advanced synthetic or semisynthetic strategies for scalable production (Blunt et al., 2022)

5. Regulatory and Legal Barriers

Access to marine genetic resources is governed by international regulations such as the Nagoya Protocol on Access and Benefit-Sharing, which can complicate sample collection, intellectual property rights, and cross-border research collaborations (Arrieta et al., 2021).

CONCLUSION

Marine pharmacognosy represents a rapidly advancing frontier in natural product research, offering immense potential for novel drug discovery and development. The world’s oceans, covering nearly 70% of the Earth’s surface, harbor an extraordinary diversity of organisms that produce structurally unique and biologically potent secondary metabolites. These compounds have shown promising pharmacological activities, including anticancer, antimicrobial, antiviral, anti-inflammatory, and antioxidant properties. Carroll, A. R., Copp, B. R., Grkovic, T., Keyzers, R. A., & Prinsep, M. R. (2025). Marine natural products. Natural Product Reports, 42, 257-297.

REFERENCE

1. Carroll, A. R., Copp, B. R., Grkovic, T., Keyzers, R. A., & Prinsep, M. R. (2025). Marine natural products. Natural Product Reports, 42, 257-297.
2. El-Seedi, H. R., Refaey, M. S., Elias, N., et al. (2025). Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023). Natural Products and Bioprospecting, 15, Article 13.
3. Mayer, A. M. S., Lehmann, V. K. B., Swanson-Mungerson, M., et al. (2024). Marine pharmacology in 2019-2021: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Marine Drugs, 22(7):309
4. Haque, N., Parveen, S., Tang, T., Wei, J., & Huang, Z. (2022). Marine Natural Products in Clinical Use. Marine Drugs, 20(10):528.
5. Mishra, Harish Kumar. (2023). Pharmacognosy of marine natural products: Potential for drug discovery. Innovations in Pharmacy Planet, 11(3):48-52.
6. Ganguly, P., Saha, P., Chatterjee, S., &Pati, P. P. (2025). Natural Marine Species Bioactive Compounds and their Ethnopharmacological Approach from Ecological Biodiversity: Sustainable Therapeutic Properties. Pharmacognosy Research, 17(3), 697-706.
7. “Marine Natural Products - Chemistry, Biology and Applications” (the annual reviews in Natural Product Reports) for years 2022-2023. Particularly the 2024 issue that described ~1417 new compounds from marine sources. Carroll et al. 2024.
8. Riaz, M. (2022). Marine Pharmacognosy: Exploring the Untapped Potential of Marine Organisms in Drug Discovery. Journal of Pharmacognosy & Natural Products, 8:216.
9. “Review of Biology and Ecology of Pharmaceutical Marine Plants” by Emily Mevers et al., Journal of Natural Products, 2021, 84(1), 183
10. The potential of marine natural products and their synthetic derivatives as drugs targeting ion channels. European Journal of Medicinal Chemistry, 2024.
11. Progress in the discovery and development of anticancer agents from marine cyanobacteria. Natural Product Reports, 2025 (covering data till April 2024).
12. From Life in the Sea to the Clinic: The Marine Drugs Approved and under Clinical Trial. Cappello, E. &Nieri, P., Life, 2021.
13. Marine Drugs: A Review. Gupta, M., Kumari, A., Rankawat, A., et al. 2023. Asian Journal of Pharmaceutical Research and Development, 11(4), 155-161.
14. Review of Pharmaceuticals in Marine and Coastal Environments: Occurrence, Effects and Challenges in a Changing World. Journal of Natural Products, 2022, 85(1):315.
15. “Marine Compounds and Cancer: Updates 2022.” Marine Drugs, 2022, 20(12):759.
16. Santaniello, G., Nebbioso, A., Altucci, L., & Conte, M. (recent). Recent Advancement in Anticancer Compounds from Marine Organisms: Approval, Use and Bioinformatic Approaches to Predict New Targets. (available as review)
17. Animal-associated marine Acidobacteria with a rich natural product repertoire. Leopold-Messer, S., Chepkirui, C., Mabesoone, M. F. J., et al. (2024). (preprint)
18. Potential Antimicrobial Activity of Marine Sponge Neopetrosiaexigua. Majali, I., Qaralleh, H. N., Idid, S. Z., et al. 2019. (preprint)
19. Mohamed, R., et al. (2020). Marine Drugs - “Marine Drugs in Clinical Use” shows how many marine compounds have become drugs. Haque N.
20. Natural Marine Products as Drug Leads: A Recent Overview of Bioactivity and Mechanistic Insights. (2025).
21. Review on marine pharmacology and marine pharmaceuticals: marine natural products and their relevant biological activities (2019-2021). From Mayer group.
22. Review on marine monographs and strategies to extract biomolecules from seafood or marine waste. Gupta et al. (2023) Marine Drugs: A Review.
23. Research & Reviews: Marine Pharmacognosy and its Classification. Mumthaj Peer Mohaideen (2022).
24. Femi-Adepoju, et al. Biomedical Potentials of Aquatic Plants (seaweeds etc.) – Pharmacognosy Reviews 2023;17(34):320-331.
25. Review on ethnopharmacological approach of marine bioactive compounds, sustainable therapeutic properties. (Ganguly et al., 2025) S.