Delight College of Pharmacy, Koregaon Bhima, Pune, Maharashtra, India-412216
The body is covered in protective layers of skin. Herbal cream made from plants calms and hydrates. Succulent aloe vera, which moisturizes, heals, and lessens pain, is frequently used in treatments. It has been used for hundreds of years to treat injuries and burns on the skin. The goal of this study is to evaluate aloe vera pharmaceutically by creating and testing a herbal gel for the treatment of skin disorders.For the creation of the herbal skin gel, aloe vera, honey, glycerin, and carbopol were used. In order to assess the formulation and ensure that it is safe for human health, evaluation parameters were also carried out. Aloe vera gel, glycerin, coconut oil, rose water, honey, and other components were used in the formulation of the aloe vera gel. Aloe vera's moisturizing and antibacterial qualities shield skin from microbial deterioration. Herbal gel is made for use in tropical medicine. Aloe vera is combined with polymers in gels to give skin a hydrating and synergistic effect. Globally, the use of herbal treatments is growing in popularity. An excellent example is the use of glycerin, honey, and aloe vera in the creation of a herbal gel.
Tropical and subtropical areas are home to the aloe vera cactus. The Arabic term "Alloeh," which means "shining bitter substance," and the Latin word "Vera," which means "true," are the sources of "Aloe Vera."1,2. Aloe barbadensis miller is the scientific name for aloe vera. It is a succulent, pea-green, xerophytic annual that resembles a tree or shrub. The aloe plant has long, triangular leaves that are very juicy. The highest These leaves are 20 inches long and 5 inches wide. Recently, translucent parenchymal gel was removed from the midrib of the leaf. In certain cases, drying methods are used to produce aloe vera concentrate; on other times, it is mixed with water to produce aloe juice products 3. Pericyclic tubules, which are found along the leaf's yellowish-green epidermis, facilitate the exudation of latex. This molecule is also the source of anthraquinones, which are used as laxatives4. Over 90% of the 300 recognized species of aloe in the world are found in South Africa, Madagascar, and Arabia5. The quantities of active chemicals vary somewhat between species6. Aloe Vera is regarded as one of the earliest plants used by humans for skin care. This plant has been used in herbal therapy since the first century AD, according to study7. According to research, Aloe Vera (AV) gel contains calming qualities that can help with a number of skin conditions, such as burns, wounds, insect bites, and inflammation. Aloe Vera's anti-inflammatory, antiseptic, antibacterial, anti-tumor, skin protective, and anti-diabetic qualities make it essential for wound healing8,9. By encouraging moisture retention, improving cell mobility, increasing collagen formation, and lowering inflammation, aloe vera aids in the healing of wounds10. Aloe vera is a plant without a lengthy stem that usually grows to a height of 60–100 cm (24–39 inches). Offshoots, often known as cuttings, are how it reproduces. Some types have thick, meaty leaves that range in hue from green to gray-green, with white spots on the top and lower stem surfaces11. A number of substances included in aloe vera leaves, such as acetylated mannans, polymannans, anthraquinone, glycosides, anthrones, and different lectins, are being studied for their bioactivity12. Aloe vera can aid with erythema, ulcers, skin integrity, and moisture13. Aloe vera's capacity to lessen scarring can help with a variety of ailments, including psoriasis, mouth sores, ulcers, diabetes, herpes, bedsores, and burns. AV is quite good for keeping skin smooth, moisturized, and taut14. Aloe vera gel is a crucial component of many cosmetic products, including moisturizers and sunscreens. AV gel contains folic acid, vitamins C and E, vitamin B12, vitamin A, and other B-group vitamins, as well as 19 of the 20-necessary amino acids15. In the same way that vitamin A derivatives may be used to counteract the obvious indications of aging, some believe the gel can be used in cosmetics. A slight burn can be immediately treated by slicing a fresh leaf and applying the gel within16. Aloe barbadensis Miller is the scientific name for aloe vera, a plant that is a member of the lily family. At its base, it has a rosette of dense green leaves. An aloe vera leaf has two layers of epidermis, or skin, with the outer layer shielding the mesophyll underneath. The mesophyll is composed of parenchyma cells and chlorenchyma cells with thicker walls. Aloe vera gel is made from the parenchyma cells of the aloe vera plant and is a transparent, slimy jelly. Aloe products frequently need to go through preparatory processes like drying, boiling, or grinding before they can be utilized. During processing, the polysaccharides may undergo irreversible changes. This might significantly change their initial structure and, consequently, their purported physiological and pharmacological properties. Aloe vera juice extraction from the pulp of the leaves has become a global business due to its extensive culinary use. Specifically, health beverages that don't require frequent bathroom breaks have been made with Aloe vera gel17.
1.1. Pharmacological properties of aloe vera gel
MATERIAL AND METHODS
2.1. Plant Material
Aloe vera In this composition, honey was used as a plant material. Aloe vera was gathered at the Lucknow Model College of Pharmacy's Botanical Garden. The honey was bought at the Krishna Nagar local market in Lucknow.
2.1.1. Aloe-Vera
Aloe vera is a well-known medical plant that has antibacterial and antioxidant qualities. It could lessen dental plaque, hasten the healing of wounds, stop wrinkles, and control blood sugar.
Aloe Vera's Advantages
Figure2 Aloe-Vera
2.1.2. Honey
Honey's extended shelf life and compatibility with a variety of chemicals make it a great preservative for aloe. Along with a variety of amino acids, vitamins, minerals, iron, zinc, and antioxidants, sugar makes up the majority of honey. Honey is used for its many health advantages, such as its antibacterial, antioxidant, and anti-inflammatory qualities. Honey promotes a healthy and young appearance by keeping moisture in the skin's deeper layers19,20.
Figure3 Honey
2.2. Chemicals
Glycerin and carbopol were gathered from the Lucknow Model College of Pharmacy's chemical storage area.
2.2.1. Carbopol 940
The ability to increase viscosity is demonstrated by carbopol 940. It was chosen for the Aloe vera herbal gel's wound-healing properties since it demonstrated good spreadability and consistency21.
2.2.2. Glycerine
Glycerine quickly relieves scalp irritation. Aloe vera provides comfort for sun-damaged skin and hair.Rashes and skin patches gradually disappear while using organic aloe vera. While glycerine gives skin and hair shine, aloe vera retains moisture22.
2.3. Method
2.3.1. Formulation and preparation of aloe vera gel
1. First, trim the plant's new aloe leaves.
2. Rinse the leaves with cold water after cutting.
3. Cut off a few pieces from the bottom and remove any yellow gel.
4. To remove the outer layer of leaves, use a knife or vegetable peeler.
5. Using a spoon or knife, remove the gel from the leaves.
6. Put the aloe gel in a mortar and pestle.
7. Using a mortar and pestle, homogenize the gel.
8. The collected gel was put in an ice cube pan and frozen.
9. Incorporate honey into the aloe vera leaf freeze gel.
10. The formulation was ready.
11. To make the mixture more elegant, coloring agents and preservatives were added23.
2.4. Evaluation of herbal aloe-vera gel
Evaluation research is characterized as a type of methodical and disciplined investigation that is conducted to determine an evaluation or appraisal of an item, program, practice, activity, or system in order to provide data that will be useful for making decisions.
2.4.1. Organoleptic Properties
The organoleptic qualities of the herbal gel are assessed using visual assessment techniques. This evaluation looked at color, odor, texture, and condition.
2.4.2. Absorption test
The gel was applied to the skin and massaged until it was fully absorbed in order to conduct the absorption test.
2.4.3. Skin Irritancy test
In order to measure irritation reactions such swelling, itching, and redness on the skin, a formulation was applied to the back of the hand and left for 15 minutes.
2.4.4. Homogeneity test
The homogeneity test was evaluated by touch and visual examination.
2.4.5. pH Test
A digital pH meter was used to measure the pH of this all-herbal Aloe-vera Gel.
2.4.6. Spread-ability test
A 500 mg gel was placed between two slides. A 200 g weight was placed on the top slide. The excess mixture was discarded once the weight was removed. A 100 g load was placed on the upper slide, which was fastened to a non-bending rope, while the lower slide was fixed to the machine. It was noted how long it took for the top slide to come off. Through touch inspection, we evaluated the lotion formulation's smoothness by rubbing the gel between their fingers and noting its texture. We noted if the gel felt harsh, uniform, clumped, or smooth24.
RESULTS AND DISCUSSION
Aloe vera gel, glycerin, coconut oil, rose water, honey, and other components were used in the formulation of the aloe vera gel. Aloe vera's moisturizing and antibacterial qualities shield skin from microbial deterioration. Glycerin contains anti-aging properties. The herbal body lotion was assessed using a number of criteria, including as physiochemical parameters, pH, washability, irritancy, homogeneity, viscosity, smoothness, etc., that are used to assess the formulation's performance and quality. The impact of various formulation constituents was examined. The formulation's physiochemical characteristics include its white hue, pleasant odor, and semi-solid state. The formulation has a neutral pH and high washability.
Table 1 Result of evaluation parameter of Herbal Aloe-Vera Skin Gel
CONCLUSION
We may conclude from the aforementioned study that herbal gel is intended for usage in warm climates. Gels contain aloe vera to keep the skin moisturized and to improve their compatibility. Globally, herbal formulations are gaining popularity. The attempt to create a herbal gel with aloe vera, honey, and turmeric powder is excellent. Aloe Vera increases skin moisture. It eliminates cuts, fissures, and uneven areas. Aloe-vera gel helps feed the skin and restore its natural posture because of its anti-inflammatory, anti-acne, anti-oxidant, anti-diabetic, nonirritating, and deeply penetrating properties. It also has a hydrating and calming effect. It is now quite difficult to cure different skin conditions without experiencing any negative side effects. One major benefit of the herbal formulation is that it has no negative side effects. As a result, the herbal gel formulation in this study demonstrates a good attempt at formulation. Aloe Vera, honey, Carbopol 940, and glycerin are all included in this mixture. The formulation in the current investigation showed good flow properties and improved stability at room temperature. This composition shows no irritating effects and is compatible with a variety of skin types. Additionally, it protects and nourishes the skin from the elements.
REFERENCE
Akshay Rupnawar, Prachi Lokhande*, Aman Mujawar, Ayeshabano Hawaldar, Pharmaceutical Assessment of Aloe Vera Skin Gel: A Herbal Formulation and its Potential Benefits, Int. J. Sci. R. Tech., 2025, 2 (12), 132-138. https://doi.org/10.5281/zenodo.17864715
10.5281/zenodo.17864715
