Delight College of Pharmacy, Koregaon Bhima, Pune, Maharashtra, India-412216
The body is covered in protective layers of skin. Herbal cream made from plants calms and hydrates. Succulent aloe vera, which moisturizes, heals, and lessens pain, is frequently used in treatments. It has been used for hundreds of years to treat injuries and burns on the skin. The goal of this study is to evaluate aloe vera pharmaceutically by creating and testing a herbal gel for the treatment of skin disorders.For the creation of the herbal skin gel, aloe vera, honey, glycerin, and carbopol were used. In order to assess the formulation and ensure that it is safe for human health, evaluation parameters were also carried out. Aloe vera gel, glycerin, coconut oil, rose water, honey, and other components were used in the formulation of the aloe vera gel. Aloe vera's moisturizing and antibacterial qualities shield skin from microbial deterioration. Herbal gel is made for use in tropical medicine. Aloe vera is combined with polymers in gels to give skin a hydrating and synergistic effect. Globally, the use of herbal treatments is growing in popularity. An excellent example is the use of glycerin, honey, and aloe vera in the creation of a herbal gel.
Tropical and subtropical areas are home to the aloe vera cactus. The Arabic term "Alloeh," which means "shining bitter substance," and the Latin word "Vera," which means "true," are the sources of "Aloe Vera."1,2. Aloe barbadensis miller is the scientific name for aloe vera. It is a succulent, pea-green, xerophytic annual that resembles a tree or shrub. The aloe plant has long, triangular leaves that are very juicy. The highest These leaves are 20 inches long and 5 inches wide. Recently, translucent parenchymal gel was removed from the midrib of the leaf. In certain cases, drying methods are used to produce aloe vera concentrate; on other times, it is mixed with water to produce aloe juice products 3. Pericyclic tubules, which are found along the leaf's yellowish-green epidermis, facilitate the exudation of latex. This molecule is also the source of anthraquinones, which are used as laxatives4. Over 90% of the 300 recognized species of aloe in the world are found in South Africa, Madagascar, and Arabia5. The quantities of active chemicals vary somewhat between species6. Aloe Vera is regarded as one of the earliest plants used by humans for skin care. This plant has been used in herbal therapy since the first century AD, according to study7. According to research, Aloe Vera (AV) gel contains calming qualities that can help with a number of skin conditions, such as burns, wounds, insect bites, and inflammation. Aloe Vera's anti-inflammatory, antiseptic, antibacterial, anti-tumor, skin protective, and anti-diabetic qualities make it essential for wound healing8,9. By encouraging moisture retention, improving cell mobility, increasing collagen formation, and lowering inflammation, aloe vera aids in the healing of wounds10. Aloe vera is a plant without a lengthy stem that usually grows to a height of 60–100 cm (24–39 inches). Offshoots, often known as cuttings, are how it reproduces. Some types have thick, meaty leaves that range in hue from green to gray-green, with white spots on the top and lower stem surfaces11. A number of substances included in aloe vera leaves, such as acetylated mannans, polymannans, anthraquinone, glycosides, anthrones, and different lectins, are being studied for their bioactivity12. Aloe vera can aid with erythema, ulcers, skin integrity, and moisture13. Aloe vera's capacity to lessen scarring can help with a variety of ailments, including psoriasis, mouth sores, ulcers, diabetes, herpes, bedsores, and burns. AV is quite good for keeping skin smooth, moisturized, and taut14. Aloe vera gel is a crucial component of many cosmetic products, including moisturizers and sunscreens. AV gel contains folic acid, vitamins C and E, vitamin B12, vitamin A, and other B-group vitamins, as well as 19 of the 20-necessary amino acids15. In the same way that vitamin A derivatives may be used to counteract the obvious indications of aging, some believe the gel can be used in cosmetics. A slight burn can be immediately treated by slicing a fresh leaf and applying the gel within16. Aloe barbadensis Miller is the scientific name for aloe vera, a plant that is a member of the lily family. At its base, it has a rosette of dense green leaves. An aloe vera leaf has two layers of epidermis, or skin, with the outer layer shielding the mesophyll underneath. The mesophyll is composed of parenchyma cells and chlorenchyma cells with thicker walls. Aloe vera gel is made from the parenchyma cells of the aloe vera plant and is a transparent, slimy jelly. Aloe products frequently need to go through preparatory processes like drying, boiling, or grinding before they can be utilized. During processing, the polysaccharides may undergo irreversible changes. This might significantly change their initial structure and, consequently, their purported physiological and pharmacological properties. Aloe vera juice extraction from the pulp of the leaves has become a global business due to its extensive culinary use. Specifically, health beverages that don't require frequent bathroom breaks have been made with Aloe vera gel17.
1.1. Pharmacological properties of aloe vera gel
MATERIAL AND METHODS
2.1. Plant Material
Aloe vera In this composition, honey was used as a plant material. Aloe vera was gathered at the Lucknow Model College of Pharmacy's Botanical Garden. The honey was bought at the Krishna Nagar local market in Lucknow.
2.1.1. Aloe-Vera
Aloe vera is a well-known medical plant that has antibacterial and antioxidant qualities. It could lessen dental plaque, hasten the healing of wounds, stop wrinkles, and control blood sugar.
Aloe Vera's Advantages
Akshay Rupnawar, Prachi Lokhande*, Aman Mujawar, Ayeshabano Hawaldar, Pharmaceutical Assessment of Aloe Vera Skin Gel: A Herbal Formulation and its Potential Benefits, Int. J. Sci. R. Tech., 2025, 2 (12), 132-138. https://doi.org/10.5281/zenodo.17864715
10.5281/zenodo.17864715
