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Abstract

Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and raw fibers. The health benefits of ginger are mainly attributed to its phenolic compounds, such as gingerols and shogaols. Accumulated investigations have demonstrated that ginger possesses multiple biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, cardiovascular protective, respiratory protective, anti-obesity, antidiabetic, antinausea, and antiemetic activities. In this review, we summarize current knowledge about the bioactive compounds and bioactivities of ginger, and the mechanisms of action are also discussed. We hope that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.

Keywords

Phytomedicine, Ginger, Mechanism of action of Ginger, Application of Ginger

Introduction

Phytomedicine is the use of plants, plant parts, or substances derived from plants, such as essential oils and extracts, for the purpose of preventing and treating diseases and promoting overall health. It encompasses a wide range of applications, including herbal teas, topical applications like salves and creams, and inhalation therapies. The practice is rooted in ancient traditions, continues to be explored with modern scientific methods to understand the efficacy, quality, and safety of these plant-based remedies. 

Key Aspects of Phytomedicine:

  • Herbal Products: 

These are plant-based products used internally or externally to maintain health or treat conditions, according to Johns Hopkins Medicine. 

  • Standardization: 

For their use as medicines, these plant-derived products are often standardized to ensure consistent quality and therapeutic effectiveness. 

  • Forms of Application: 

Phytomedicines can be administered in various forms: 

    • Ingestion: As herbal teas or oral supplements. 
    • Topical Application: As oils, salves, creams, and lotions for skin conditions or wounds. 
    • Inhalation: Using aromatic oils or steam for therapeutic effects. 

Examples of Phytomedicines and Their Uses: 

  1. Beta-sitosterol: May help with skin conditions, wound healing, and heart health.
  2. Ginger: May help alleviate nausea and vomiting.
  3. Green Tea: Research suggests it might help fight cancerous tumors’ or improve certain diabetes-related conditions.

It involves the analysis and characterization of plant extracts and their components to ensure quality, safety, and effectiveness. Phytomedicines are also known as herbal medicines or botanicals and are available in various forms, such as pills, teas, or topical preparations.

Ginger

Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. [2] It is an herbaceous perennial that grows annual pseudostems (false stems made of the rolled bases of leaves) about one meter tall, bearing narrow leaf blades. The inflorescences bear flowers having pale yellow petals with purple edges, and arise directly from the rhizome on separate shoots. [3] Ginger is in the family Zingiberaceae, which also includes turmeric (Curcuma longa), [4] cardamom (Elettaria cardamomum), and galangal. Ginger originated in Maritime Southeast Asia and was likely domesticated first by the Austronesian peoples. It was transported with them throughout the Indo-Pacific during the Austronesian expansion (c. 5,000 BP), reaching as far as Hawaii.

Scientific classification

Kingdom:

Plantae

Clade:

Tracheophytes

Clade:

Angiosperms

Clade:

Monocots

Clade:

Commelinids

Order:

Zingiberales

Family:

Zingiberaceae

Genus:

Zingiber

Species:

Z. officinale

Binomial name

Zingiber officinale

Morphology of Ginger

Plant Type 

  • Perennial herb: 

Ginger is a perennial plant, meaning it lives for more than two years and grows from its rhizome.

  • Monocotyledon: 

Ginger is a monocot, a type of flowering plant that has one cotyledon (seed leaf).

Rhizome

  • Function: 
  • The rhizome is a modified, horizontal, underground stem that stores food and energy. It is often mistakenly called a root but is technically a stem. 
  • Appearance: 
  • It is thick, fleshy, knobby, and branched in a palmate (hand-like) manner, with a buff or pale yellow color on the outside and a paler yellowish interior. 
  • Features: 
  • The rhizome has adventitious roots growing from it, as well as nodes, internodes, scale leaves, and buds (the "eyes") from which new shoots emerge. 
  • Shoots and Pseudostem 
  • Pseudostem: Above ground, ginger forms a pseudostem, which is not a true stem but a hollow tube made of tightly rolled leaf sheaths.
  • Height: This pseudostem can reach a height of up to 1 meter (about 3 feet).

Leaves

  • Arrangement: The leaves are alternate (arranged one after another, not opposite each other) and grow in two neat rows along the pseudostem. 
  • Shape: They are long, narrow, and lance-shaped, resembling blades of grass. 

Flowers

  • Appearance: Ginger flowers are rarely seen, but when they occur, they are small, yellow-green with purple markings, and arranged in a cone-shaped spike surrounded by overlapping green bracts. 
  • Inflorescence: The flower spike (inflorescence) emerges directly from the rhizome. 

Extraction of Ginger Extract

Ginger extraction methods range from simple home techniques like grating and juicing or making a honey-ginger syrup to industrial processes such as steam distillation, solvent extraction (e.g., using ethanol), and ultrasonic-assisted extraction for more potent extracts like gingerol and ginger oil.

Phytochemistry Of Ginger

Ginger's main phytochemicals are its essential oil and phenolic compounds, notably gingerols, which are responsible for its pungent taste and potent antioxidant and anti-inflammatory properties. Other key compounds include shogaols, formed from gingerols during processing, paradols, and zingerone. Ginger also contains various other phytochemical groups such as flavonoids, terpenoids, steroids, and alkaloids. 

Mechanism of Action of Ginger

Ginger works through multiple mechanisms, primarily due to compounds like gingerol and shogaol, to provide its beneficial effects. Key mechanisms include acting as a potent antioxidant, reducing oxidative stress; anti-inflammatory actions, by inhibiting pro-inflammatory pathways like NF-κB; anti-emetic effects, by antagonizing serotonin (5-HT3) and muscarinic (M3) receptors in the gut; and promoting gastrointestinal motility, which can relieve nausea. It also has antitumor properties by modulating genetic pathways and inducing apoptosis, and contributes to metabolic regulation by improving glucose and lipid metabolism. 

APPLICATION OF GINGER

Ginger is used in cooking for its spicy-sweet flavor and in medicine for its potential to relieve nausea, aid digestion, reduce inflammation, and manage pain. It contains gingerol, a compound with antioxidant and antimicrobial properties that may also help lower blood sugar and cholesterol levels. You can consume ginger fresh in various dishes like soups and smoothies, as tea, or in powdered form as a supplement.  

Culinary Uses

  • Flavoring: 

Add fresh or powdered ginger to curries, stir-fries, soups, sauces, and desserts to enhance their taste. 

  • Beverages: 

Infuse fresh ginger into hot water for tea, add it to smoothies, or mix it into coffee to boost its flavor and health benefits. 

  • Baking: 

Incorporate ginger into baked goods like pancakes for added warmth and spice. 

Medicinal & Health Benefits

  • Nausea Relief: Helps alleviate nausea and vomiting, whether from motion sickness, morning sickness, or chemotherapy. 
  • Digestive Aid: Can soothe indigestion, ease gas, and help with bloating by relaxing digestive muscles. 
  • Anti-inflammatory: Reduces inflammation, which can help with pain from arthritis, muscle soreness, and menstrual cramps. 
  • Antioxidant Properties: Gingerol in ginger helps fight germs and protects against cellular damage from free radicals, supporting the immune system. 
  • Blood Sugar & Cholesterol: May help improve blood sugar levels and lower "bad" LDL cholesterol. 
  • Pain Management: Assists in reducing pain associated with migraines and arthritis. 

How to Use Ginger

  • Fresh Root: 

Use fresh ginger root by mincing, slicing, or grating it into dishes and teas. 

  • Powdered Ginger: 

Add dried ginger powder to recipes or as a supplement. 

  • Supplements: 

Take ginger supplements, often in pill or capsule form, for concentrated health benefits. 

  • DIY Remedies: 

Make ginger tea by steeping fresh or powdered ginger in hot water, or create a paste for topical application on the forehead for headaches. 

CONCLUSION

Ginger is a widely used spice and traditional remedy, recognized for its potent bioactive compounds like gingerols and shogaols, which possess significant anti-inflammatory, antioxidant, and antiemetic (anti-nausea) properties. It is a safe and inexpensive treatment for nausea and vomiting, particularly during pregnancy, and shows promise for managing conditions such as osteoarthritis, diabetes, and cardiovascular disorders, although further large-scale, standardized research is needed to confirm these effects. While beneficial in dietary amounts, excessive consumption can cause gastric upset, and individuals with health conditions or on medication should consult a doctor before taking ginger supplements.

REFERENCE

  1. "Zingiber officinale". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 10 December 2017.
  2.  "Ginger, NCCIH Herbs at a Glance". US NCCIH. 1 December 2020. Retrieved 4 September 2023.
  3.  Sutarno H, Hadad EA, Brink M (1999). "Zingiber officinale Roscoe". In De Guzman CC, Siemonsma JS (eds.). Plant resources of South-East Asia: no.13: Spices. Leiden (Netherlands): Backhuys Publishers. pp. 238–244.
  4.  "Curcuma longa L." Plants of the World Online, Kew Science, Kew Gardens, Royal Botanic Gardens, Kew, England. 2018. Retrieved 26 March 2018.
  5.  "Zingiber officinale Roscoe". Kew Science, Plants of the World Online. Royal Botanic Gardens, Kew. 2017. Retrieved 25 November 2017.
  6.  McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, et al. (October 2016). "Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review". JAMA (Systematic review). 316 (13): 1392–1401. doi:10.1001/jama.2016.14337. PMID 27701665.
  7.  Lee J, Oh H (March 2013). "Ginger as an antiemetic modality for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis". Oncol Nurs Forum. 40 (2): 163–70. doi: 10.1188/13.ONF.163-170. PMID 23448741.
  8.  "Ginger". Drugs.com. 26 September 2022. Retrieved 4 September 2023.
  9.  ζιγγ?βερις. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Project.
  10.  Das AP (2002). Perspectives of Plant Biodiversity: Proceedings of National Seminar on Plant Biodiversity – Systematics, Conservation and Ethnobotany, Department of Botany, North Bengal University, November 9-11, 2000. Bishen Singh Mahendra Pal Singh. p. 292. ISBN 978-81-211-0298-8.
  11.  Caldwell R (1 January 1998). A Comparative Grammar of the Dravidian Or South-Indian Family of Languages (3rd ed.). New Delhi: Asian Educational Services. ISBN 978-81-206-0117-8.
  12.  Harper D. "ginger". Online Etymology Dictionary.
  13.  Ravindran P, Nirmal Babu K (2016). Ginger: The Genus Zingiber. Boca Raton: CRC Press. p. 7. ISBN 978-1-4200-2336-7.
  14.  Singh RJ (2011). Genetic Resources, Chromosome Engineering, and Crop Improvement. Medicinal Plants. Vol. 6. Boca Raton: CRC Press. p. 398. ISBN 978-1-4200-7386-7.
  15.  Viestad A (2007). Where Flavor Was Born: Recipes and Culinary Travels Along the Indian Ocean Spice Route. San Francisco: Chronicle Books. p. 89. ISBN 978-0-8118-4965-4.
  16.  Ross M (2008). "Other cultivated plants". In Ross M, Pawley A, Osmond M (eds.). The lexicon of Proto Oceanic: The culture and environment of ancestral Oceanic society. Vol. 3. Canberra: Pacific Linguistics. pp. 389–426. ISBN 978-0-85883-589-4.
  17.  Robert B, Trussel S (2013). "The Austronesian Comparative Dictionary: A Work in Progress". Ocean. Linguist. 52 (2): 493–523. doi:10.1353/ol.2013.0016. ISSN 0029-8115. S2CID 146739541.
  18.  Zanariah U, Nordin NI, Subramaniam T (2015). "Ginger Species and Their Traditional Uses in Modern Applications". Journal of Industrial Technology. 23 (1): 59–70. doi:10.21908/jit.2015.4 (inactive 12 July 2025).
  19.  Dalby A (2002). Dangerous Tastes: The Story of Spices. University of California Press. ISBN 978-0-520-23674-5.
  20.  Kikusawa R, Reid LA (2007). "Proto who used turmeric, and how?" (PDF). In Siegel J, Lynch JD, Eades D (eds.). Language Description, History and Development: Linguistic indulgence in memory of Terry Crowley. John Benjamins Publishing Co. pp. 339–352. ISBN 978-90-272-9294-0. Archived from the original (PDF) on 25 November 2021. Retrieved 23 January 2019.
  21.  Blust R (1984). "The Austronesian Homeland: A Linguistic Perspective". Asian Perspectives. 26 (1). University of Hawai?i Press: 61. JSTOR 42928105.
  22.  Mahdi W (1999). "The Dispersal of Austronesian boat forms in the Indian Ocean". In Blench R, Spriggs M (eds.). Archaeology and Language III: Artefacts languages, and texts. One World Archaeology. Vol. 34. London: Routledge. pp. 144–179. ISBN 978-0-415-51870-3.
  23.  Beaujard P (2011). "The first migrants to Madagascar and their introduction of plants: linguistic and ethnological evidence" (PDF). Azania: Archaeological Research in Africa. 46 (2): 169–189. doi:10.1080/0067270X.2011.580142. S2CID 55763047.
  24.  Doran CF, Dixon C (1991). South East Asia in the World-Economy. Cambridge: Cambridge University Press. ISBN 978-0-521-31237-0.
  25.  Lee Dian Rainey (2010). Confucius and Confucianism: The Essentials. Wiley-Blackwell. p. 10. ISBN 978-1-4443-2360-3.
  26.  Pickersgill B (2005). Prance G, Nesbitt M (eds.). The Cultural History of Plants. Routledge. pp. 163–164. ISBN 0-415-92746-3.
  27.  Dalby A (2000). Dangerous Tastes: The Story of Spices. University of California Press. p. 78. ISBN 0-520-22789-1.
  28.  Larsson M, Foley B (26 January 2023). "The king's spice cabinet–Plant remains from Gribshunden, a 15th century royal shipwreck in the Baltic Sea". PLOS ONE. 18 (1) e0281010. Bibcode:2023PLoSO.1881010L. doi: 10.1371/journal.pone.0281010. ISSN 1932-6203. PMC 9879437. PMID 36701280.
  29.  Aram B (2015). "Caribbean ginger and Atlantic trade, 1570–1648". Journal of Global History. 10 (3). Cambridge, UK: 410–430. doi:10.1017/S1740022815000200.
  30.  Watt JM, Breyer-Brandwijk MG (1962). Medicinal and Poisonous Plants of Southern and Eastern Africa. E & S Livingstone.

Reference

  1. "Zingiber officinale". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 10 December 2017.
  2.  "Ginger, NCCIH Herbs at a Glance". US NCCIH. 1 December 2020. Retrieved 4 September 2023.
  3.  Sutarno H, Hadad EA, Brink M (1999). "Zingiber officinale Roscoe". In De Guzman CC, Siemonsma JS (eds.). Plant resources of South-East Asia: no.13: Spices. Leiden (Netherlands): Backhuys Publishers. pp. 238–244.
  4.  "Curcuma longa L." Plants of the World Online, Kew Science, Kew Gardens, Royal Botanic Gardens, Kew, England. 2018. Retrieved 26 March 2018.
  5.  "Zingiber officinale Roscoe". Kew Science, Plants of the World Online. Royal Botanic Gardens, Kew. 2017. Retrieved 25 November 2017.
  6.  McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, et al. (October 2016). "Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review". JAMA (Systematic review). 316 (13): 1392–1401. doi:10.1001/jama.2016.14337. PMID 27701665.
  7.  Lee J, Oh H (March 2013). "Ginger as an antiemetic modality for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis". Oncol Nurs Forum. 40 (2): 163–70. doi: 10.1188/13.ONF.163-170. PMID 23448741.
  8.  "Ginger". Drugs.com. 26 September 2022. Retrieved 4 September 2023.
  9.  ζιγγ?βερις. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Project.
  10.  Das AP (2002). Perspectives of Plant Biodiversity: Proceedings of National Seminar on Plant Biodiversity – Systematics, Conservation and Ethnobotany, Department of Botany, North Bengal University, November 9-11, 2000. Bishen Singh Mahendra Pal Singh. p. 292. ISBN 978-81-211-0298-8.
  11.  Caldwell R (1 January 1998). A Comparative Grammar of the Dravidian Or South-Indian Family of Languages (3rd ed.). New Delhi: Asian Educational Services. ISBN 978-81-206-0117-8.
  12.  Harper D. "ginger". Online Etymology Dictionary.
  13.  Ravindran P, Nirmal Babu K (2016). Ginger: The Genus Zingiber. Boca Raton: CRC Press. p. 7. ISBN 978-1-4200-2336-7.
  14.  Singh RJ (2011). Genetic Resources, Chromosome Engineering, and Crop Improvement. Medicinal Plants. Vol. 6. Boca Raton: CRC Press. p. 398. ISBN 978-1-4200-7386-7.
  15.  Viestad A (2007). Where Flavor Was Born: Recipes and Culinary Travels Along the Indian Ocean Spice Route. San Francisco: Chronicle Books. p. 89. ISBN 978-0-8118-4965-4.
  16.  Ross M (2008). "Other cultivated plants". In Ross M, Pawley A, Osmond M (eds.). The lexicon of Proto Oceanic: The culture and environment of ancestral Oceanic society. Vol. 3. Canberra: Pacific Linguistics. pp. 389–426. ISBN 978-0-85883-589-4.
  17.  Robert B, Trussel S (2013). "The Austronesian Comparative Dictionary: A Work in Progress". Ocean. Linguist. 52 (2): 493–523. doi:10.1353/ol.2013.0016. ISSN 0029-8115. S2CID 146739541.
  18.  Zanariah U, Nordin NI, Subramaniam T (2015). "Ginger Species and Their Traditional Uses in Modern Applications". Journal of Industrial Technology. 23 (1): 59–70. doi:10.21908/jit.2015.4 (inactive 12 July 2025).
  19.  Dalby A (2002). Dangerous Tastes: The Story of Spices. University of California Press. ISBN 978-0-520-23674-5.
  20.  Kikusawa R, Reid LA (2007). "Proto who used turmeric, and how?" (PDF). In Siegel J, Lynch JD, Eades D (eds.). Language Description, History and Development: Linguistic indulgence in memory of Terry Crowley. John Benjamins Publishing Co. pp. 339–352. ISBN 978-90-272-9294-0. Archived from the original (PDF) on 25 November 2021. Retrieved 23 January 2019.
  21.  Blust R (1984). "The Austronesian Homeland: A Linguistic Perspective". Asian Perspectives. 26 (1). University of Hawai?i Press: 61. JSTOR 42928105.
  22.  Mahdi W (1999). "The Dispersal of Austronesian boat forms in the Indian Ocean". In Blench R, Spriggs M (eds.). Archaeology and Language III: Artefacts languages, and texts. One World Archaeology. Vol. 34. London: Routledge. pp. 144–179. ISBN 978-0-415-51870-3.
  23.  Beaujard P (2011). "The first migrants to Madagascar and their introduction of plants: linguistic and ethnological evidence" (PDF). Azania: Archaeological Research in Africa. 46 (2): 169–189. doi:10.1080/0067270X.2011.580142. S2CID 55763047.
  24.  Doran CF, Dixon C (1991). South East Asia in the World-Economy. Cambridge: Cambridge University Press. ISBN 978-0-521-31237-0.
  25.  Lee Dian Rainey (2010). Confucius and Confucianism: The Essentials. Wiley-Blackwell. p. 10. ISBN 978-1-4443-2360-3.
  26.  Pickersgill B (2005). Prance G, Nesbitt M (eds.). The Cultural History of Plants. Routledge. pp. 163–164. ISBN 0-415-92746-3.
  27.  Dalby A (2000). Dangerous Tastes: The Story of Spices. University of California Press. p. 78. ISBN 0-520-22789-1.
  28.  Larsson M, Foley B (26 January 2023). "The king's spice cabinet–Plant remains from Gribshunden, a 15th century royal shipwreck in the Baltic Sea". PLOS ONE. 18 (1) e0281010. Bibcode:2023PLoSO.1881010L. doi: 10.1371/journal.pone.0281010. ISSN 1932-6203. PMC 9879437. PMID 36701280.
  29.  Aram B (2015). "Caribbean ginger and Atlantic trade, 1570–1648". Journal of Global History. 10 (3). Cambridge, UK: 410–430. doi:10.1017/S1740022815000200.
  30.  Watt JM, Breyer-Brandwijk MG (1962). Medicinal and Poisonous Plants of Southern and Eastern Africa. E & S Livingstone.

Photo
Pragya Yadav
Corresponding author

Pharmacy, SCPM College of Pharmacy, Gonda, India

Photo
Pramod Mishra
Co-author

Pharmacy, SCPM College of Pharmacy, Gonda, India

Photo
Sujeet Pratap Singh
Co-author

Pharmacy, SCPM College of Pharmacy, Gonda, India

Photo
Tarkeshwar Prasad. Shukla
Co-author

Pharmacy, SCPM College of Pharmacy, Gonda, India

Pragya Yadav*, Pramod Mishra, Sujeet Pratap Singh, Tarkeshwar Prasad. Shukla, Review -Phytomedicine (Ginger), Int. J. Sci. R. Tech., 2025, 2 (12), 89-96. https://doi.org/10.5281/zenodo.17818540

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