Pharmacy, SCPM College of Pharmacy, Gonda, India
Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and raw fibers. The health benefits of ginger are mainly attributed to its phenolic compounds, such as gingerols and shogaols. Accumulated investigations have demonstrated that ginger possesses multiple biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, cardiovascular protective, respiratory protective, anti-obesity, antidiabetic, antinausea, and antiemetic activities. In this review, we summarize current knowledge about the bioactive compounds and bioactivities of ginger, and the mechanisms of action are also discussed. We hope that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.
Phytomedicine is the use of plants, plant parts, or substances derived from plants, such as essential oils and extracts, for the purpose of preventing and treating diseases and promoting overall health. It encompasses a wide range of applications, including herbal teas, topical applications like salves and creams, and inhalation therapies. The practice is rooted in ancient traditions, continues to be explored with modern scientific methods to understand the efficacy, quality, and safety of these plant-based remedies.
Key Aspects of Phytomedicine:
These are plant-based products used internally or externally to maintain health or treat conditions, according to Johns Hopkins Medicine.
For their use as medicines, these plant-derived products are often standardized to ensure consistent quality and therapeutic effectiveness.
Phytomedicines can be administered in various forms:
Examples of Phytomedicines and Their Uses:
It involves the analysis and characterization of plant extracts and their components to ensure quality, safety, and effectiveness. Phytomedicines are also known as herbal medicines or botanicals and are available in various forms, such as pills, teas, or topical preparations.
Ginger
Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. [2] It is an herbaceous perennial that grows annual pseudostems (false stems made of the rolled bases of leaves) about one meter tall, bearing narrow leaf blades. The inflorescences bear flowers having pale yellow petals with purple edges, and arise directly from the rhizome on separate shoots. [3] Ginger is in the family Zingiberaceae, which also includes turmeric (Curcuma longa), [4] cardamom (Elettaria cardamomum), and galangal. Ginger originated in Maritime Southeast Asia and was likely domesticated first by the Austronesian peoples. It was transported with them throughout the Indo-Pacific during the Austronesian expansion (c. 5,000 BP), reaching as far as Hawaii.
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Kingdom: |
Plantae |
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Clade: |
Tracheophytes |
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Clade: |
Angiosperms |
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Clade: |
Monocots |
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Clade: |
Commelinids |
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Order: |
Zingiberales |
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Family: |
Zingiberaceae |
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Genus: |
Zingiber |
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Species: |
Z. officinale |
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Binomial name |
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Zingiber officinale |
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Morphology of Ginger
Plant Type
Ginger is a perennial plant, meaning it lives for more than two years and grows from its rhizome.
Ginger is a monocot, a type of flowering plant that has one cotyledon (seed leaf).
Rhizome
Leaves
Flowers
Extraction of Ginger Extract
Ginger extraction methods range from simple home techniques like grating and juicing or making a honey-ginger syrup to industrial processes such as steam distillation, solvent extraction (e.g., using ethanol), and ultrasonic-assisted extraction for more potent extracts like gingerol and ginger oil.
Phytochemistry Of Ginger
Ginger's main phytochemicals are its essential oil and phenolic compounds, notably gingerols, which are responsible for its pungent taste and potent antioxidant and anti-inflammatory properties. Other key compounds include shogaols, formed from gingerols during processing, paradols, and zingerone. Ginger also contains various other phytochemical groups such as flavonoids, terpenoids, steroids, and alkaloids.
Mechanism of Action of Ginger
Ginger works through multiple mechanisms, primarily due to compounds like gingerol and shogaol, to provide its beneficial effects. Key mechanisms include acting as a potent antioxidant, reducing oxidative stress; anti-inflammatory actions, by inhibiting pro-inflammatory pathways like NF-κB; anti-emetic effects, by antagonizing serotonin (5-HT3) and muscarinic (M3) receptors in the gut; and promoting gastrointestinal motility, which can relieve nausea. It also has antitumor properties by modulating genetic pathways and inducing apoptosis, and contributes to metabolic regulation by improving glucose and lipid metabolism.
APPLICATION OF GINGER
Ginger is used in cooking for its spicy-sweet flavor and in medicine for its potential to relieve nausea, aid digestion, reduce inflammation, and manage pain. It contains gingerol, a compound with antioxidant and antimicrobial properties that may also help lower blood sugar and cholesterol levels. You can consume ginger fresh in various dishes like soups and smoothies, as tea, or in powdered form as a supplement.
Culinary Uses
Add fresh or powdered ginger to curries, stir-fries, soups, sauces, and desserts to enhance their taste.
Infuse fresh ginger into hot water for tea, add it to smoothies, or mix it into coffee to boost its flavor and health benefits.
Incorporate ginger into baked goods like pancakes for added warmth and spice.
Medicinal & Health Benefits
How to Use Ginger
Use fresh ginger root by mincing, slicing, or grating it into dishes and teas.
Add dried ginger powder to recipes or as a supplement.
Take ginger supplements, often in pill or capsule form, for concentrated health benefits.
Make ginger tea by steeping fresh or powdered ginger in hot water, or create a paste for topical application on the forehead for headaches.
CONCLUSION
Ginger is a widely used spice and traditional remedy, recognized for its potent bioactive compounds like gingerols and shogaols, which possess significant anti-inflammatory, antioxidant, and antiemetic (anti-nausea) properties. It is a safe and inexpensive treatment for nausea and vomiting, particularly during pregnancy, and shows promise for managing conditions such as osteoarthritis, diabetes, and cardiovascular disorders, although further large-scale, standardized research is needed to confirm these effects. While beneficial in dietary amounts, excessive consumption can cause gastric upset, and individuals with health conditions or on medication should consult a doctor before taking ginger supplements.
REFERENCE
Pragya Yadav*, Pramod Mishra, Sujeet Pratap Singh, Tarkeshwar Prasad. Shukla, Review -Phytomedicine (Ginger), Int. J. Sci. R. Tech., 2025, 2 (12), 89-96. https://doi.org/10.5281/zenodo.17818540
10.5281/zenodo.17818540