Abstract
Aspergillus niger represents a significant yet underestimated threat to public health, particularly through its widespread contamination of onion peels and subsequent impact on asthma patients. This comprehensive review examines the pathophysiology, epidemiology, and clinical implications of A. niger exposure in vulnerable populations. The ubiquitous nature of this black mold species in agricultural environments, combined with its potent allergenic and mycotoxigenic properties, creates a perfect storm for respiratory complications in asthmatic individuals. Through systematic analysis of current literature, this review demonstrates how occupational and domestic exposure to contaminated onion peels can trigger severe respiratory symptoms, including hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and acute asthma exacerbations. The mechanisms underlying these pathological responses involve complex immunological cascades, mycotoxin-induced tissue damage, and airway hyperresponsiveness. Evidence suggests that even minimal exposure to A. niger spores from contaminated onion peels can precipitate life-threatening respiratory crises in susceptible individuals. This review calls for enhanced awareness, improved detection methods, and comprehensive prevention strategies to protect asthma patients from this hidden environmental hazard.
Keywords
Aspergillus niger, onion contamination, asthma, mycotoxins, respiratory allergens, occupational health
Introduction
The Intersection of food safety and respiratory health represents a critical yet often overlooked domain in contemporary medical research. Aspergillus niger, commonly recognized as black mold, has emerged as a formidable pathogen with far-reaching implications for human health (Bensch et al., 2018). This saprophytic fungus demonstrates remarkable adaptability and ubiquity, colonizing diverse environments ranging from agricultural settings to domestic kitchens (Mitchell et al., 2016; Pattinson & Lucas, 2019). The growing body of evidence suggests that onion peels serve as particularly favorable substrates for A. niger proliferation, creating significant health hazards for asthmatic individuals who encounter these contaminated materials during food processing or preparation (Rodriguez-Martinez et al., 2020). The clinical significance of A. niger exposure extends beyond simple allergic reactions, encompassing a spectrum of severe respiratory conditions that can prove life-threatening in susceptible populations (Thompson & Davies, 2021; Khalil et al., 2019). Recent epidemiological studies have revealed alarming correlations between occupational exposure to contaminated onion products and the development of hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis (ABPA), and severe asthma exacerbations (Nelson et al., 2018; Foster & Williams, 2020). The pathophysiological mechanisms underlying these conditions involve complex immunological responses, mycotoxin-induced cellular damage, and disruption of pulmonary homeostasis (Garcia-Lopez et al., 2021). Despite mounting evidence of its clinical importance, A. niger contamination of food products remains inadequately addressed in current public health policies and clinical practice guidelines (Anderson & Burke, 2019; Patel et al., 2022). This review aims to synthesize current knowledge regarding the hidden menace posed by A. niger in onion peels and its devastating consequences for asthma patients, providing a comprehensive analysis of pathophysiology, clinical manifestations, and prevention strategies.
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Arnab Roy
Corresponding author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Ankita Singh
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Mukti Oraon
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Priya Kumari
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Nirjala Kumari
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Ananya Mishra
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Indu Sharma
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Bharti Kumari
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Parinika Kumari
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Rohit Kumar
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Sumit Oraon
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Abhinav Keshri
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Anuj Kumar Rajak
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Anjali Prasad
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Pushpa Kumari
Co-author
Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand-835219, India
Suman Roy
Co-author
Department of Pharmacy, Shubham University, Bhopal, Madhya Pradesh-462010, India
Biswasi Topno
Co-author
Department of Pharmacy, Shubham University, Bhopal, Madhya Pradesh-462010, India
Nikhil Kumar Sharma
Co-author
Department of Pharmacy, Shubham University, Bhopal, Madhya Pradesh-462010, India
Ankita Singh, Mukti Oraon, Priya Kumari, Nirjala Kumari, Ananya Mishra, Indu Sharma, Bharti Kumari, Parinika Kumari, Rohit Kumar, Sumit Oraon, Abhinav Keshri, Anuj Kumar Rajak, Anjali Prasad, Pushpa Kumari, Suman Roy, Biswasi Topno, Nikhil Kumar Sharma, Arnab Roy*, The Hidden Menace of Aspergillus Niger: Unveiling the Fungal Contamination of Onion Peels and Its Devastating Consequences for Asthma Patients, Int. J. Sci. R. Tech., 2025, 2 (9), 111-120. https://doi.org/10.5281/zenodo.17120088
10.5281/zenodo.17120088
