Tinospora Cordifolia (Guduchi): Phytochemistry, Pharmacological Activities and Therapeutic Potential

Reference

1. Preeti S. Tinospora cordifolia (Amrita)-a miracle herb and lifeline too many
2. Pandey MM, Rastogi S, Rawat AK; Indian herbal Drug for general healthcare: An overview. Internet J Altern Med, 2008; 6:1.
3. Singh and Saxena 2017; Upadhyay et al. 2010).
4. S. Saha, S. Ghosh, Tinospora cordifolia: one plant, many roles, Ancient Sci. Life 31 (2012) 151–159, https://doi.org/10.4103/0257-7941.107344.
5. D. Singh, P.K. Chaudhuri, Chemistry and pharmacology of Tinospora cordifolia, Nat. Prod. Commun. 12 (2017) 299–308.
6. B. Singh, S. Nathawat, R.A. Sharma, Ethnopharmacological and phytochemical attributes of Indian Tinospora species: a comprehensive review, Arab. J. Chem. 14 (10) (2021) 1–75.
7. D.S. Nagarkatti, N.N. Rege, N.K. Desai, S.A. Dahanukar, Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage, J. Postgrad. Med. 40 (1994) 65–67.
8. P.K. Nair, S.J. Melnick, R. Ramachandran, E. Escalon, C. Ramachandran, Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora Cordifolia, Int. Immunopharm. 6 (2006) 1815–1824.
9. P.K. Gupta, P. Chakraborty, S. Kumar, P.K. Singh, M.G. Rajan, K.B. Sainis, S. Kulkarni, G1-4A, a polysaccharide from Tinospora cordifolia inhibits the survival of Mycobacterium tuberculosis by modulating host immune responses in TLR4 dependent manner, PLoS One 11 (2016) e0154725, https://doi.org/10.1371/ Journal.pone. 0154725.eCollection.2016.
10. V. Shanthi, R. Nelson, Antibacterial activity of Tinospora cordifolia (Willd) Hook. F. Thoms on urinary tract pathogens, Int J Curr Microbiol App Sci 2 (2013) 190–194.
11. K.M. Sannegowda, S.H. Venkatesha, K.D. Moudgil, Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and Bone damage, Int. J. Immunopathol. Pharmacol. 28 (4) (2015) 521–531.
12. a) Patil D, Gautam M, Mishra S, Kulkarni P, Suresh K, Gairola S, Jadhav S, Patwardhan B. (2010) Quantitative determination of protoberberine Alkaloids in Tinospora cordifolia by RP-LC-DAD. Chromatographia, 71, 341-345; (b) Srinivasan GV, Unnikrishnan KP, Shree ABR, Balachandran I. (2008) HPLC estimation of berberine in Tinospora cordifolia and Tinospora sinensis. Indian Journal of Pharmaceutical Sciences, 70, 96-99.
13. Bala M, Verma PK, Awashi S, Kumar N, Lal B, Singh B. (2015) Chemical prospection of important ayurvedic plant Tinospora cordifolia by UPLC-DAD-ESI-QTOF-MS/MS and NMR. Natural Product Communications, 10, 43-48.
14. Singh D, Chaudhuri PK. (2015) (+) Corydine from the stems of Tinospora cordifolia. Asian Journal of Chemistry, 27, 1567
15. Alexander CP, Kirubakaran CJW, Michael RD. (2010) Water soluble fraction of Tinospora cordifolia leaves enhanced the non-specific immune Mechanisms and disease resistance in Oreochromis mossambicus. Fish Shellfish Immunology, 29, 765-72.
16. Singh N, Singh SM, Shrivastava P. (2003) Immunomodulatory effect of Tinospora cordifolia in tumor-bearing host. Orient Pharmacy and Experimental Medicine, 3, 72-79.
17. Singh N, Singh SM, Shrivastava P. (2004) Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through Activation of tumor-associated macrophages. Immunotoxicology and Immunopharmacology, 26, 145-162.
18. Dahanukar SA, Kulkarani RA, Rege NN. (2000) Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology, 32, 81-118.
19. Thatte UM, Chhabria SC, Karandikar SM, Dahanukar SA. (1987) Protective effects of Indian medicinal plants against cyclophosphamide Neutropenia. Journal of Postgraduate Medicine, 33, 185-188.
20. Singh, D.; Chaudhuri, P.K. Chemistry and pharmacology of Tinospora cordifolia. Nat. Prod. Commun. 2017, 12, 299–308. [CrossRef][PubMed]
21. Sharma, B.; Dutt, V.; Kaur, N.; Mittal, A.; Dabur, R. Tinospora cordifolia protects from skeletal muscle atrophy by alleviating Oxidative stress and inflammation induced by sciatic denervation. J. Ethnopharmacol. 2020, 254, 112720. [CrossRef] [PubMed]
22. Kumar, P.; Kaur, S.; Goswami, M.; Singh, S.; Sharma, A.; Mehta, N. Antioxidant and antimicrobial efficacy of giloy (TinosporaCordifolia) stem powder in spent hen meat patties under aerobic packaging at refrigeration temperature (4 ± 1?C). J. Food Process.Preserv. 2021, 45, e15772. [CrossRef]
23. Parveen, A.; Wang, Y.H.; Fantoukh, O.; Alhusban, M.; Raman, V.; Ali, Z.; Khan, I.A. Development of a chemical fingerprint as a Tool to distinguish closely related Tinospora species and quantitation of marker compounds. J. Pharm. Biomed. Anal. 2020, 178,112894. [CrossRef] [PubMed]
24. Gangan, V.D.; Pradhan, P.; Sipahimalani, A.T.; Banerji, A. Cordifolisides A, B, C: Norditerpene furan glycosides from Tinospora Cordifolia. Phytochemistry 1994, 37, 781–786. [CrossRef]
25. Kapil, A.; Sharma, S. Immunopotentiating compounds from Tinospora cordifolia. J. Ethnopharmacol. 1997, 58, 89–95. [CrossRef]
26. Maurya, R.; Wazir, V.; Tyagi, A.; Kapil, R.S. Clerodane diterpenoids from Tinospora cordifolia. Phytochemistry 1995, 38, 659–661. [CrossRef]
27. Khan, M.A.; Gray, A.I.; Waterman, P.F. Tinosporaside, an 18-norclerodane glucoside from Tinospora cordifolia. Phytochemistry 1989,28, 273–275. [CrossRef]
28. Choudhary, N.; Siddiqui, M.B.; Azmat, S.; Khatoon, S. Tinospora cordifolia: Ethnobotany, phytopharmacology and phytochemistry Aspects. Int. J. Pharm. Sci. Res. 2013, 4, 891–899.
29. Pathak, A.K.; Agarwal, P.K.; Jain, D.C.; Sharma, R.P.; Howarth, O.W. NMR studies of 20β-hydroxyecdysone, a steroid; isolated From Tinospora cordifolia. Indian J. Chem. Sec. B 1995, 34, 674–676.
30. Maurya, R.; Handa, S.S. Tinocordifolin, a sesquiterpene from Tinospora cordifolia. Phytochemistry 1998, 49, 1343–1345. [CrossRef]
31. Pathak, A.K.; Jain, D.C.; Sharma, R.P. Chemistry and biological activities of the genera Tinaspora. Int. J. Pharmacogn. 1995, 33,277–287. [CrossRef]
32. Upadhyay, N.; Ganie, S.A.; Agnihotri, R.K.; Sharma, R. Free Radical Scavenging Activity of Tinospora cordifolia (Willd.) Miers. J.pharmacogn. phytochem .2014.3,63,69
33. Nair, P.K.R.; Melnick, S.J.; Ramachandran, R.; Escalon, E.; Ramachandran, C. Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia. Int. Immunopharmacol. 2006, 6, 1815–1824. [CrossRef]
34. Bala, M.; Pratap, K.; Verma, P.K.; Singh, B.; Padwad, Y. Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC. J. Ethnopharmacol. 2015, 175, 131–137. [CrossRef]
35. Sharma, A.K.; Kishore, K.; Sharma, D.; Srinivasan, B.P.; Agarwal, S.S.; Sharma, A.; Singh, S.K.; Gaur, S.; Jatav, V.S. Cardioprotective Activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats. J. Biomed.Res. 2011, 25, 280–286. [CrossRef]
36. Maurya, R.; Handa, S.S. Tinocordifolin, a sesquiterpene from Tinospora cordifolia. Phytochemistry 1998, 49, 1343–1345. [CrossRef]
37. singh et al., 2003; 2004.
38. Nair et al., 2006.
39. Thatte et al., 1987
40. Sannegowda et al., 2015.
41. V. Sivakumar, M.S.D. Rajan, Hypoglycemic and antioxidant activity of Tinospora cordifolia in experimental diabetes, Int. J. Pharma Sci. Res. 2 (2011) 608–613.
42. M.B. Patel, S. Mishra, Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia, Phytomedicine 18 (2011) 1045–1052.
43. M.K. Sangeetha, H.R.B. Raghavendran, V. Gayathri, H.R. Vasanthi, Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in Experimentally induced type 2 diabetes in rats, J. Nat. Med. 65 (2011) 544–550.
44. N.F. Puranik, K.F. Kammar, S. Devi, Anti-diabetic activity of Tinospora cordifolia (Willd.) in streptozotocin diabetic rats; does it act like sulfonylureas? Turk. J. Med. Sci. 40 (2010) 265–270.
45. A. Tomar, A. Singh, G. Thakur, A.K. Agarwal, V.K. Singh, In-vitro and in-vivo study of Tinospora cordifolia as an antidiabetic agent in rat, Biochem. Cell. Biol. 10 (2010) 175–177.
46. M. Rajalakshmi, J. Eliza, C.E. Priya, A. Nirmala, P. Daisy, Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin induced diabetic rats, Afr J Pharm Pharmacol 3 (2009) 171–180.
47. V. Sivakumar, A.M. Sadiq, Hypoglycemic activity of Tinospora cordifolia in Alloxan induced diabetic rats, Bioscan 4 (2009) 75–78.
48. S.S. Reddy, P. Ramatholisamma, B. Ramesh, R. Baskar, D.S. Kumari, Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities In carbohydrate and lipid metabolism in Wistar rats, Horm. Metab. Res. 41 (2009) 741–746.
49. S.S. Reddy, P. Ramatholisamma, R. Karuna, D.S. Kumari, Preventive effect of Tinospora cordifolia against high-fructose diet induced insulin resistance and Oxidative stress in male Wistar rats, Food Chem. Toxicol. 47 (2009) 2224–2229.
50. A.D. Chougale, V.A. Ghadyale, S.N. Panaskar, A.U. Arvindekar, Alpha glucosidase inhibition by stem extract of Tinospora cordifolia, J. Enzym. Inhib. Med. Chem. 24 (2009) 998–1001.
51. S. Sengupta, A. Mukherjee, R. Goswami, S. Basu, Hypoglycemic activity of the antioxidant saponarin, characterized as alpha glucosidase inhibitor present in Tinospora cordifolia, J. Enzym. Inhib. Med. Chem. 24 (2009) 684–690.
52. P.S. Prince, M. Padmanabhan, V.P. Menon, Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver And kidney, Phytother Res. 18 (2004) 785–787.
53. P.S. Prince, N. Kamalakkannan, V.P. Menon, Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats, Acta Pol. Pharm. 61 (2004) 283–287.
54. Y. Zhang, X. Li, D. Zou, W. Liu, J. Yang, N. Zhu, L. Huo, M. Wang, J. Hong, P. Wu, G. Ren, G. Ning, Treatment of type 2 diabetes and dyslipidemia with the Natural plant alkaloid berberine, J. Clin. Endocrinol. Metab. 93 (2008) 2559–2565.
55. N.K. Puranik, K.F. Kammar, S. Devi, Modulation of morphology and some gluconeogenic enzymes activity by Tinospora cordifolia (Willd.) in diabetic rat Kidney, Biomed. Res. 18 (2007) 179–183.
56. A. Kar, B.K. Choudhary, N.G. Bandyopadhyay, Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats, J. Ethnopharmacol. 84 (2003) 105–108.
57. P.S.M. Prince, V.P. Menon, Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats, Phytother Res. 17 (2003) 410–413.
58. S.S. Rathi, J.K. Grover, V. Vikrant, N.R. Biswas, Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts, Phytother Res. 16 (2002) 774–777.
59. J.K. Grover, S.S. Rathi, V. Vats, Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plants (Eugenia Jambolana, Mucurna pruriens and Tinospora cordifolia) extracts, Indian J. Exp. Biol. 40 (2002) 273–276.
60. J.K. Grover, V. Vats, S.S. Rathi, R. Dawar, Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic Mice, J. Ethnopharmacol. 73(2001) 233–238.
61. P. Stanely, M. Prince, V.P. Menon, Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats, J. Ethnopharmacol. 70 (2000) 915.
62. K.S. Dhaliwal, Method and Composition for Treatment of Diabetes, 1999. US patent 5886029.
63. P.S.M. Prince, V.P. Menon, G. Gunasekaran, Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats, J. Ethnopharmacol. 64 (1999) 53–57.
64. N. Wadood, A. Wadood, S.A. Shah, Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits, Planta Med. 58 (1992) 131–136.
65. K. Raghunathan, P.V. Sharma, Effect of Tinospora cordifolia Miers (Guduchi) on adrenaline induced hyperglycaemia, J. Res. Indian Med. 4 (1969) 59–62.
66. M.L. Dhar, M.M. Dhar, B.N. Dhawan, B.N. Mehrotra, C. Ray, Screening of Indian plants for biological activity, Indian J. Exp. Biol. 6 (1968) 232–247.
67. M. George, P.R. Venkatraman, K.M. Pandalai, Investigation on plant antibiotics, part II: a search for antibiotic substances in some Indian medicinal plants, J. Sci. Ind. Res. 3 (1947) 42–46.
68. T. Klangjareonchai, S. Putadechakum, C. Roongpisuthipong, Review of anti-hyperglycemic effect of Tinospora crispa, Walailak J. Sci. Technol. 12 (2015) 403–406.
69. M.B. Patel, S. Mishra, Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia, Phytomedicine 18 (2011) 1045–1052.
70. M.B. Patel, S. Mishra, Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia, Pharma Innov. 5 (2016) 104.
71. V. Sivakumar, M.S.D. Rajan, Hypoglycemic and antioxidant activity of Tinospora cordifolia in experimental diabetes, Int. J. Pharma Sci. Res. 2 (2011) 608–613.
72. M.B. Patel, S. Mishra, Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia, Phytomedicine 18 (2011) 1045–1052.
73. M.K. Sangeetha, H.R.B. Raghavendran, V. Gayathri, H.R. Vasanthi, Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in Experimentally induced type 2 diabetes in rats, J. Nat. Med. 65 (2011) 544–550.
74. Aher V, Wahi AK. Biotechnological Approach to evaluate The Immunomodulatory activity of ethanolic Extract of Tinospora cordifolia stem (mango plant climber). Iranian journal of Pharmaceutical research: IJPR.2012;11(3):863
75. Khaleque A, Maith MA, Huq MS, Abul BK. Tinospora cordifolia IV. Isolation of Heptacosanol, ß sitosterol and three other compounds tinosporine, cordifol and Cordifolone. Pakistan J. Sci. Industry Res. 1970; 14:481-3.
76. Prashant Tiwari, Puravi Nayak, Shakti Ketan Prusty, Pratap Kumar Sahu. Phytochemistry And Pharmacology of Tinospora cordifolia: A Review. SRP. 2018;9(1):70-8.
77. Jagetia GC, Nayak V, Vidyasagar MS. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Letters. 1998;127(1-2):71-82.
78. Singh RP, Banerjee S, Kumar PV, Raveesha KA, Rao AR. Tinospora cordifolia induces Enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid Peroxidation in mice. Phytomedicine. 2006;13(1-2):74-84.
79. Thippeswamy G, Salimath BP. Induction of caspase-3 activated DNase mediated Apoptosis by hexane fraction of Tinospora cordifolia in EAT cells. Environmental Toxicology and Pharmacology. 2007;23(2):212-20.
80. Verma R, Chaudhary HS, Agrawal RC. Evaluation of anticarcinogenic and Antimutagenic effect of Tinospora cordifolia in experimental animals. J Chem Pharm Res. 2011;3(6):877-881.
81. Ali H, Dixit S. Extraction optimization of Tinospora cordifolia and assessment of the Anticancer activity of its alkaloid palmatine. The Scientific World Journal. 2013.
82. Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 2011;18(12):1045-52.
83. Singh K, Panghal M, Kadyan S, Chaudhary U, Yadav JP. Antibacterial activity of Synthesized silver nanoparticles from Tinospora cordifolia against multi drug Resistant strains of Pseudomonas aeruginosa isolated from burn patients. Journal of Nanomedicine and Nanotechnology. 2014;5(2):1.
84. Narayanan AS, Raja SS, Ponmurugan K, Kandekar SC, Natarajaseenivasan K, Maripandi A, Mandeel QA. Antibacterial activity of selected medicinal plants against Multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India. Beneficial Microbes. 2011;2(3):235-43.
85. Jyachandran R, Xavier TF, Anand SP. Antibacterial activity of stem extracts of Tinospora Cordifolia (Willd) Hook. F and Thomson. Ancient science of life. 2003;23(1):40-3.
86. Tambekar DH, Khante BS, Chandak BR, Titare AS, Boralkar SS, Aghadte SN. Screening Of antibacterial potentials of some medicinal plants from Melghat forest in India. African Journal of Traditional, Complementary and Alternative Medicines. 2009;6(3) pp:228-32.
87. Duraipandiyan V, Ignacimuthu S, Balakrishna K, AL-Harbi NA. Antimicrobial activity Of Tinospora cordifolia: an ethnomedicinal plant. Asian Journal of Traditional Medicines2012;7(2): 59-65.
88. Shefali C, Nilofer S. Gaduchi-the best ayurvedic herb. The Pharma Innovation. 2013;2(4):97-102.
89. Recent scientific reviews and journals ScienceDirect, ResearchGate, and Cell Press
90. J. Mittal, M.M. Sharma, A. Batra Tinospora cordifolia: a multipurpose medicinal plant-A, Review Journal of Medicinal Plants Studies, 2 (2014), pp. 32-47
91. V.A.Badar, V.R. Thawani, P.T. Wakode, M.P. Shrivastava, K.J. Gharpure, L.L. Hingorani, R.M. Khiyani Efficacy of Tinospora cordifolia in allergic rhinitis J. Ethnopharmacol., 96 (2005),. 445-449, 10.1016/j.jep.2004.09.034
92. A. Upadhyay, K. Kumar, A. Kumar, H. Mishra Tinospora cordifolia (Willd.) Hook. F. and Thoms. (Guduchi) – validation of the Ayurvedic pharmacology through experimental and clinical studies Int. J. Ayurveda Res., 1 (2010), p. 112
93. N.N. Rege, U.M. Thatte, S.A. Dahanukar Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine Phytother Res., 13 (1999), pp. 275-
94. P.N. Manjrekar, C.I. Jolly, S. Narayanan Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis Fitoterapia, 71 (2000), pp. 254-257.