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Ashokrao Mane College of Pharmacy Peth Vadgaon 416112 Maharashtra India
Cancer remains one of the leading causes of mortality worldwide, prompting continuous exploration of effective, safe, and affordable treatment options. Herbal drugs, derived from medicinal plants, have gained increasing attention as potential therapeutic agents due to their bioactive compounds with anticancer properties. Recent advances in phytochemistry and molecular pharmacology have elucidated the mechanisms through which herbal compounds such as curcumin, resveratrol, quercetin, and berberine exert anti-proliferative, pro-apoptotic, anti-angiogenic, and immune-modulatory effects on cancer cells. Clinical and preclinical studies have shown promising results, highlighting the potential of herbal drugs to enhance the efficacy of conventional therapies and reduce treatment-associated toxicity. Despite their therapeutic promise, challenges such as variability in plant composition, lack of standardization, limited bioavailability, and regulatory hurdles remain. This review explores the current landscape of herbal drugs in cancer therapy, evaluates their clinical efficacy, and discusses future directions for integrating these natural compounds into mainstream oncological treatment, emphasizing the need for rigorous scientific validation and technological innovations to unlock their full potential.
In both high-income countries (HICs) and low- and middle-income ones (LMICs), cancer is a major cause of death worldwide among women. Furthermore, in high-, mid-, and low-income countries alike, the burden of cancer is increasing, prompting an additional impact due to population growth and aging. Females constitute 49.5% of total world population; however, they form a greater proportion of the population over 60 years, [2] where cancer is incident almost exclusively in HICs and LMICs, due to contrasting life expectancy and leading causes of death. To reduce the incidence of the abovementioned cancers, the prevention of carcinogenic infections and efforts aimed at lifestyle improvement are essential. [3] In low-income countries, infection-related cancers are predominant. In contrast, in high-income countries lung, colorectal [4], and breast cancer, which are strongly associated with lifestyle-related risk factors, including cigarette smoking, alcohol consumption [5] , and obesity, display high incidence rates. In addition, the prevalence of cancer-screening tests and the identification of high-risk patients [6], including those with inherited cancer syndromes, are important for improving survival. [7] There is scant communication between patients and health care providers with respect to CIM and herbal remedies [8] Unmonitored use can cause many adverse effects and herb-drug interactions, especially for cancer patients currently undergoing treatment [9]. For example, herbs with potent antioxidant properties may antagonize radiation therapy and selected chemotherapeutic agents [10] hemorrhagic potential of anticoagulant herbs may further enhance the action of anticoagulant/ant platelet drugs with a consequent increase in risk for bleeding phytoestrogenic herbs may alter the pharmacokinetics of hormonal therapies immunomodulant herbs may antagonize the action of immunosuppressive drugs Research into ethno botanical evidence is a key contributor in the search for herbs possesing anticancer activity[11] ; A few medicinal herbs, such as Catharanthus roseus and Pacific yew (Taxus brevifolia), have been in use for centuries as traditional medicine and, in later years, found their way as sources of chemotherapy drugs (vincristine/vinblastine and taxanes[12] More, drug-derived types from herbs include morphine (which is derived from the opium poppy-Papaver somniferous , psychoactive substances from Cannabis sativa, and have both been used for therapeutic pain relief and enhancement of the patient's well-being[13] . Further search for other herbs can, therefore, lead to identification of more herbs with anticancer activity such as ayurvedic medicine in India and shamans in the Amazon rain forest. [14] The purpose of intervention is to provide benefits to beneficiaries. Most importantly, for clinical trials this means measuring the differential impact of treatments against some outcome [15]. Thus, the selection of appropriate outcomes becomes critical to the assessment of whether any intervention is superior to others [16]. This review is about research explaining the selection of outcome measures for use in clinical trials for children below 16 years [17]. On that note, for the purpose of this review, a child is defined by age, and not in the literal sense of offspring. [18]
Mechanism Action of Herbal Drugs On Cancer Treatment:
There are a lot of herbs that contain bioactive compounds which can act against the oxidative stress inflicted on the body. They include polyphenolic, flavonoid, and vitamin antioxidants that neutralize the [19] free radical activity that occurs in the body. Free radicals are unstable molecules capable of damaging the cells and DNA within the organism. The consequence is cancer [20]. Thus, the herbal medicines may protect the cells from damage caused by carcinogens via the mediation of oxidative stress. [21] For instance, curcumin (known in turmeric) effectively prevents DNA damage leading to cancer in humans by providing enormous antioxidant impact. [22] One way in which new blood vessels from angiogenesis develop is the formation of new blood vessels that would supply nutrients for growing tumors. [23] These new blood vessels can be starved by herbal compounds, hence preventing the growth or spreading of the tumor.
Khot Nikhil*, Lohar Dayanand, Khamkar Sakshi, Jamadar Wajid, Torskar Sourabh, Karande Sankalp, Lokare Sonakshi, Herbal Drugs in Cancer Treatment: Current Advances, Efficacy, And Future Prospects in Modern Medicine, Int. J. Sci. R. Tech., 2025, 2 (5), 225-236. https://doi.org/10.5281/zenodo.15380959
10.5281/zenodo.15380959