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Abstract

Tinospora cordifolia (Willd.) Miers, often known as Guduchi or Giloy, is an important medicinal plant in ancient Ayurvedic medicine, noted for its numerous therapeutic uses. As a member of the Menispermaceae family, it contains a wide range of phytoconstituents such as alkaloids, diterpenoid lactones, glycosides, steroids, and polysaccharides, which contribute to its complex pharmacological profile. Scientific studies have demonstrated its significant immunomodulatory, antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, antibacterial, anticancer, and neuroprotective properties. The benefits are mediated by modulating critical molecular pathways such NF-?B, MAPK, and Nrf2, as well as enhancing endogenous antioxidant defence mechanisms.Guduchi's adaptogenic characteristics make it useful in treating stress-related diseases. Despite extensive preclinical data, clinical validations are rare, emphasising the importance of standardised formulations and well structured human studies. This study attempts to completely explore Tinospora cordifolia's pharmacological properties, with a focus on its potential as a natural medicinal agent in modern medicine.

Keywords

Tinospora cordifolia, Immunomodulatory activity, Antioxidant activity, Anti-inflammatory activity, Antidiabetic activity, NF-?B pathway

Introduction

Botanical name: Tinospora cordifolia: Tinospora cordifolia (Willd.) Miers belongs to the Menispermaceae family. The research "Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases" (Abiltarova, 2022) confirms this identification and classification. Common names: Guduchi, Giloy, Amrita: Guduchi (sanskrit), Giloy (Hindi), Amrita, which means "immortal" in Sanskrit, refers to its revitalising effects. These names are well documented in the following peer-reviewed article: Tinospora cordifolia, a therapeutic plant (Jauk et al., 2023). Family: Menispermaceae. This categorisation is validated in the peer-reviewed study. Tinospora cordifolia (Willd.) Miers: Defence mechanisms and tactics against oxidative stress-related disorders (Abiltarova, 2022) Tinospora cordifolia has long been utilised in Ayurvedic, Siddha, Unani, and folk medicine to treat a variety of diseases, including fever, inflammation, diabetes, gastrointestinal problems, respiratory infections, and immune-related issues. The study supports this ethnomedicinal usage. Tinospora cordifolia (Willd.) Miers: Defence mechanisms and tactics against oxidative stress-related disorders (Abiltarova, 2022). Tinospora cordifolia's ethnopharmacological relevance has been thoroughly documented in scientific literature, notably in terms of its involvement in both traditional medicinal systems and current biomedical research. Tinospora cordifolia is significant in ethnopharmacology because it has long been used in Ayurvedic, Siddha, and folk medicine systems to treat a variety of diseases. Its medicinal characteristics, including as immunomodulatory, antioxidant, antipyretic, and antidiabetic actions, are supported by both traditional literature and recent pharmacological research. Tinospora cordifolia (Willd.) Miers: Defence mechanisms and tactics against oxidative stress-related disorders (Arunachalam et al., 2022)

Reference

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Mohit ghuge
Corresponding author

Department of Pharmacology Anuradha College of Pharmacy, Chikhli, Buldhana, Maharashtra, India

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Dr. Abhaykumar Sakhare
Co-author

Department of Pharmacology Anuradha College of Pharmacy, Chikhli, Buldhana, Maharashtra, India

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Dr. Kailash Biyani
Co-author

Department of Pharmacology Anuradha College of Pharmacy, Chikhli, Buldhana, Maharashtra, India

Mohit ghuge*, Dr. Abhaykumar Sakhare, Dr. Kailash Biyani, A Comprehensive Review on Pharmacological Potential and Therapeutic Applications of Tinospora cordifolia, Int. J. Sci. R. Tech., 2025, 2 (8), 236-247. https://doi.org/10.5281/zenodo.16886154

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