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Abstract

This comprehensive review explores the pharmacological properties of two tropical fruits?Red Dragon Fruit (Hylocereus polyrhizus) and Pineapple (Ananas comosus)?focusing on their phytochemical composition and therapeutic potential. Red Dragon Fruit is rich in antioxidants such as betacyanins, flavonoids, and phenolic compounds, demonstrating significant anti-inflammatory, anticancer, antidiabetic, antimicrobial, and cardioprotective effects. Its prebiotic properties and ulcer-healing capabilities further support its role in gastrointestinal health and metabolic regulation. Pineapple, known for its proteolytic enzyme bromelain, exhibits anti-inflammatory, antioxidant, anticoagulant, anticancer, and wound-healing activities. Both fruits also show promise in treating ulcers and microbial infections. Various in-vitro and in-vivo studies confirm the efficacy of different extracts (methanolic, ethanolic, aqueous, etc.) in addressing multiple health disorders, highlighting their potential as nutraceuticals and therapeutic agents. However, despite strong preclinical evidence, more clinical trials and standardization of dosages are required for effective medical application.

Keywords

Hylocereus polyrhizus, Ananas comosus, Red Dragon Fruit, Pineapple, Herbal Medicine, Functional Foods, Natural Remedies

Introduction

Fruits are integral components of the human diet, not only because of their palatability and nutritional value but also due to their medicinal properties. Among the wide variety of fruits consumed globally, Red Dragon Fruit (Hylocereus spp.) and Pineapple (Ananas comosus) have gained prominence due to their vibrant appearance, rich phytochemical content, and diverse pharmacological activities. These tropical fruits are cultivated in many regions of the world and are appreciated not only for their exotic flavor and texture but also for their functional and therapeutic benefits. Red Dragon Fruit (Hylocereus spp.) , also known as pitaya or pitahaya, is a tropical fruit belonging to the Cactaceae family. It is widely cultivated in Southeast Asia, Central and South America, and more recently, in parts of India and Australia. The fruit originates from several species within the genus Hylocereus, with the most commonly cultivated being Hylocereus undatus, Hylocereus polyrhizus, and Hylocereus costaricensisn. Types and Color Variants Red dragon fruit can be broadly classified into the following main types, based on the color of the skin and pulp: White-fleshed Dragon Fruit (Hylocereus undatus) – This variety has a bright pink or red peel with white flesh and small black seeds. It is the most commonly available type in the global market.  Red-fleshed Dragon Fruit (Hylocereus costaricensis / Hylocereus polyrhizus) – Characterized by both red skin and deep red to magenta-colored pulp. This type is rich in betalains, giving it its distinctive hue and superior antioxidant potential.  Yellow Dragon Fruit (Selenicereus megalanthus) – Though technically from a different genus, this variety has a yellow peel with white pulp and is known for its higher sweetness and lower acidity. The intense coloration in red and yellow varieties is due to natural pigments such as betalains, anthocyanins, and carotenoids, which not only contribute to the fruit’s visual appeal but also enhance its pharmacological efficacy, particularly its antioxidant, anti-inflammatory, and anticancer properties. Pineapple (Ananas comosus), a tropical fruit belonging to the family Bromeliaceae, is native to South America and is now widely cultivated across tropical and subtropical regions around the world. It is valued not only for its unique sweet-tart flavor and juicy texture but also for its rich phytochemical profile and medicinal properties that support various pharmacological applications. Traditionally used in folk medicine, pineapple has garnered scientific attention due to its potent anti-inflammatory, antioxidant, antimicrobial, anticoagulant, and anticancer effects. Pineapple fruits are cylindrical or conical in shape, composed of fused berries, and exhibit a vibrant yellow to golden flesh when ripe. The skin may range from green to reddish-brown, depending on the maturity and cultivar. The edible pulp is succulent, fibrous, and aromatic, with the characteristic sweet acidity attributed to the presence of organic acids such as citric and malic acids. Several varieties or cultivars of pineapple are cultivated globally, including:

  • Smooth Cayenne – the most common commercial variety, known for its juiciness and high sugar-acid balance.
  • Queen – smaller in size with a more fragrant aroma and deeper yellow flesh.
  • Red Spanish – more fibrous and resistant to disease, commonly grown in the Caribbean.
  • MD2 (Del Monte Gold) – a newer hybrid known for its sweeter taste, longer shelf life, and higher vitamin C content.

Pineapple is a reservoir of essential nutrients and bioactive compounds, including vitamins (A, B1, B6, C), minerals (calcium, potassium, manganese), and dietary fiber. A key component that distinguishes pineapple from many other fruits is bromelain, a proteolytic enzyme complex predominantly found in the stem and fruit. Bromelain exhibits wide-ranging therapeutic effects, such as anti-inflammatory, antithrombotic, fibrinolytic, and digestive properties, making pineapple highly relevant in nutraceutical and pharmaceutical formulations.

  1. Plant Profile:
    1. Red Dragon:

Red dragon fruit, also called Hylocereus polyrhizus, is a tropical fruit with bright red flesh. It is grown in many countries, including India. The peel of the fruit contains natural compounds like antioxidants and flavonoids, which help protect the stomach lining. Because of these properties, red dragon fruit is studied for its ability to prevent and heal stomach ulcers.

Reference

  1. Burke, A., Smyth, E., & FitzGerald, G.A. Analgesic antipyretic agents; pharmacotherapy of gout. In L.B. Brunton, J.S. Lazo & K.L. Parker (Ed.) Goodman & Gilman's the Pharmacological Basis of Therapeutics (pp. 671-715). New York: McGraw-Hill. 2005
  2. Nadkarni AK. Indian Materia Medica.Popular Press Bldg. 2000. www.ijapbc.com
  3. Landen NX, Li Dongqing, Stahle M. Transition from inflammation to proliferation: acritical step during wound healing. Cell Mol Life Sci 2016;73(20):3861–85.www.elsevier.com/locate/jtv.
  4. Chedea VS, Jisaka M. Inhibition of soybean lipooxygenases-structural and activity models for the lipooxygenaseisoenzymes family: recent trends for enhancing the diversity and quality of soybean products. In Tech., 2005; 6: 100–13. http://iamjournal.com
  5. Akansha Shandarkar, Nikita Pawar, Arundhati kore, jagruti shelar, Anti-inflammatory Agents: A review on herbs that reduces inflammation, international journal of pharmaceutical sciences. Sci 2025, bol.3, issue 6. 444-401.https://wwwijpsjournal.com.
  6. Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and biomarkers for wound healing. Plast Reconstr Surg 2016;138(Suppl. 3)18Se28S.
  7. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 2011; 17:113e25.
  8. Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg 2017;43(Suppl. 1): S3e18
  9. Lind Holm, C.; Searle, R. Wound management for the 21st century: Combining effectiveness and efficiency.Int. Wound J. 2016, 13, 5–15. [CrossRef]
  10. Mustoe, T. Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy. Am. J. Surg. 2004, 187 (Suppl. 1), S65–S70. [CrossRef]
  11. James, G.A.; Swogger, E.; Wolcott, R.; Pulcini, E.D.; Secor, P.; Sestrich, J.; Costerton, J.W.; Stewart, P.S. Biofilms in chronic wounds. Wound Repair Regen. 2008, 16, 37–44. [CrossRef]
  12. McCarty, S.M.; Percival, S.L. Proteases and Delayed Wound Healing. Adv. Wound Care 2013, 2, 438–447. [CrossRef]
  13. Ben-Porath, I.; Weinberg, R.A. The signals and pathways activating cellular senescence. Int. J. Biochem. Cell Biol. 2005, 37, 961–976. [CrossRef] [PubMed]
  14. Schultz, G.S.; Sibbald, R.G.; Falanga, V.; Ayello, E.A.; Dowsett, C.; Harding, K.; Romanelli, M.; Stacey, M.C.; Teot, L.; Vanscheidt, W. Wound bed preparation: A systematic approach to wound management. Wound RepairRe. 2003, 11 (Suppl. 1), S1–S28. [CrossRef] [PubMed]
  15. Loots, M.A.; Lamme, E.N.; Zeegelaar, J.; Mekkes, J.R.; Bos, J.D.; Middelkoop, E. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J. Investig. Dermatol. 1998, 111, 850–857. [CrossRef] [PubMed]
  16. Kuo, P.-C.; Kao, C.-H.; Chen, J.-K. Glycated type 1 collagen induces endothelial dysfunction in culture.In Vitro Cell. Dev. Biol. Anim. 2007, 43, 338–343. [CrossRef] [PubMed]
  17. Widgerow, A.D.; King, K.; Tocco-Tussardi, I.; Banyard, D.A.; Chiang, R.; Awad, A.; Afzel, H.; Bhatnager, S.;9. Priyadarsini K.I. The chemistry of curcumin: From extraction to Therapeutic agent. Molecules. 2014; 19:20091-20112 https://doi.org/10.3390/molecules191220091
  18. Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of Curcumin. Preclinical and clinical studies. Anticancer Research. 2003; 23(1/A):363-398
  19. Rathore S, Mukim M, Curcumin: A Review for Health Benefits, International Journal of Research and Review 2020; 7(1).
  20. Lestari M.L., Indrayanto G. Curcumin. Profiles Drug Subst. Excip. Relat. Methodol. 2014; 39:113-204. https://doi.org/10.1016/B978-0-12-800173-8.00003-9.
  21. Gamage K, Dissanayake C, Angoda W, Waliwita LC, A Review on Medicinal Uses of Zingiber officinale (Ginger), International Journal of Health Sciences and Research, 2020; 10(6).
  22. Potential health benefits and scientific review of ginger Najim A. Jabir Al-Awwadi College of Pharmacy, Thi-Qar University, Iraq. 2017; 9(7):111-116. https://doi.org/10.5897/JPP2017.0459
  23. Https://draxe.com/Nutrition /anti-inflammatory herbs.
  24. Rathod GB, Parmar P. Study of association of thrombocytopenia with plasmodium vivax infection. Indian J of Med Sciences, 2017; 69: 33-35.
  25. Sahu A., Rawal N., Pangburn M. K. Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b. Biochemical Pharmacology, 1999; 57(12): 1439–1446. doi: 10.1016/s0006-2952(99)00044-1.
  26. Amaral G. P., de Carvalho N. R., Barcelos R. P., et al. Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats. Food and Chemical Toxicology, 2013; 55: 48–55. doi: 10.1016/j.fct.2012.12.038.
  27. Jucelia pizzetti Beninca, Julliana Bastos Dalmarlo, Moacir Geraldo pizzolatti, Tonia silvia frode, Analysis of the Anti-inflammatory properties of Rosrnorinus officinalis L. In mice. Food chemistry 124(2011) 468-475.www.elsevier-com//locate/food chem.
  28. The culinary institute of America (2011). The professional chef(athed).Hobaken,new sersey : wiley.p, 180. ISBN.978-0-42 135-8
  29. Rosemary, Drug.Com, 24 june.2024, Retrieved 22 march 2025.
  30. Nair R, Sellaturay S, Sriprasad S. The history of ginseng in the management of erectile dysfunction in ancient China (3500–2600 BCE). Indian J Urol 2012;28:
  31. Fenton WN. Lafitau, Joseph-François'. Dictionary of Canadian Biography, 3; 19741741–70.
  32. Jia L, Zhao Y. Current evaluation of the millennium phytomedicine-ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr MedChem 2009; 16:2475.
  33. Lee C, Wen J. Phylogeny of Panax using chloroplast trnC-trnD intergenic region and the utility of trnC–trnD in interspecific studies of plants. Mol Phylogenet Evol 2004; 31:894–903.
  34. Kim KH, Lee D, Lee HL, Kim CE, Jung K, Kang KS. Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases:past findings and future directions. J Ginseng Res 2018; 42:239e47.
  35. Wahid F, Khan T, Subhan F, Khan M, Kim Y. Ginseng pharmacology: multiple molecular targets and recent clinical trials. Drugs Future 2010; 35:399e407.
  36. Shim JS, Song MY, Yim SV, Lee SE, Park KS. Global analysis of ginsenoside Rg1protective effects in beta-amyloid-treated neuronal cells. J Ginseng Res 2017; 41:566e71.
  37. P. Pushpagadan & S.K. Tiwari, Peppermint handbook of herb & species, National Botanical Research institute,India, page no:460-478.
  38. Abid aslam maon, Akmal nazir, Muhammad Kashif iqbal khan, Tabir ahmad, Rabia zia, murid, Muhammad Abrar, The therapeutic properties & applications of aloevera:a review journal of herbal medicine, Vol. 4,page no:1-39.
  39. J. Hall, R. Bravo -clovzet, Anti-inflammatory Herbs for Arthritis, bioactive Food as Diatery Interventions for Arthritis & related Inflammatoty Disease, Chapter -46, https://dx.doi.org/10.1016/B978-0-12-397156-2-00253.2
  40. Deepika Singh, prabir k. Chaudhari, A review on phytochemical & pharmacological properties of Holybasil, industrial crops & products.www. Elsevier.com/locate/incrop.
  41. Vats, V., Yadav, S.P., Grover, J.K., 2004. Ethanolic extract of Ocimum sanctum leave partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J. Ethnopharmacol. 90, 155–160.
  42. Maria. G. Goni, sara k. Roura, Alejandra. G. Ponce, Maria.R. Moreira, Clove (Syzygium aromaticum) oils, Essential oils in food preservation, flavor & safety, chapter -39, https://dx.doi.org/10.1016/B978+0-12-416641-7-000.39-0
  43. Health Benefits of Cloves: Uses, Benefits & Side Effects https://share.google/TWhs5I58AHM5Gk90l
  44. What is cardamom? Benefits and uses of cardamom spice, https://www.mastervlass.com/articles/what-is-cardamom-benefits-and-uses-of what-is-cardamom-benefits-and-uses-ofcardamom-spice#what-is-cardamom, Accessed: July 15, 2021.
  45. 10 Health Benefits of Cardamom, Backed by Science, https://www.healthline.com/nutrition/cardamom -benefits, Accessed: July 15, 2021.
  46. A.C. Gonçalves, S. Castro, J. Paiva, C. Santos, P. Silveira, Taxonomic revision of the genus Calendula (Asteraceae) in the Iberian Peninsula and the Balearic Islands, Phytotaxa 352 (1) (2018) 1, https://doi.org/10.11646/ Phytotaxa.352.1.1.
  47. Tutin TG, Heywood VH, Burges NA, Valentine DH, Walters SM, Webb DA (Eds.), Flora Europaea: Plantaginaceae to Compositae (and Rubiaceae), 4, Cambridge University Press, Cambridge, 1964, p. 207.
  48. C. Ao, Comparative anatomy of bisexual and female florets, embryology in Calendula officinalis (Asteraceae), a naturalized horticultural plant, Sci. Hortic.114 (3) (2007) 214–219, https://doi.org/10.1016/j.scienta.2007.06.019
  49. Herbal formulations containing herbal additives. https://share.google/snJxwOFawfxWpBsOy.

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S. Swetha
Corresponding author

Aadhi Bhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu

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M. Gopi
Co-author

Aadhi Bhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu

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M. Gowri
Co-author

Aadhi Bhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu

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V. Govarthini
Co-author

Aadhi Bhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu

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K. Gowtham
Co-author

Aadhi Bhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu

S. Swetha*, M. Gopi, M. Gowri, V. Govarthini, K. Gowtham, A Comprehensive Review on the Pharmacological Activities of Hylocereus Polyrhizus and Ananas Comosus, Int. J. Sci. R. Tech., 2025, 2 (8), 381-393. https://doi.org/10.5281/zenodo.16919826

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