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  • Formulation and Evaluation of Multi Nutrition Herbal Tablet

  • 1Research Scholar, Department of Pharmacognosy, Late Narayandas Bhawandas Chhabada Institute of Pharmacy, Raigaon, Satara. Dist: Satara, Maharashtra. 415020
    2Assistant Professor, Department of Pharmacology, Late Narayandas Bhawandas Chhabada Institute of Pharmacy, Raigaon, Satara. Dist: Satara, Maharashtra. 415020
     

Abstract

This study employs the wet granulation method to develop and evaluate a multi-nutrition, herbal tablet consisting of Tulsi, Cinnamon, Clove and Ginger. The objective is to assess the tablet's quality through various factors, including thickness, hardness, weight variation, and friability. These potent herbs are incorporated due to their nutritional and therapeutic properties. The ingredients are effectively transformed into a tablet form for easy consumption using the wet granulation technique. Analyzing the tablet's physical properties provides valuable insights into its effectiveness and user acceptance. The findings of this research could offer benefits for dietary supplementation and health by improving our understanding of the formulation and quality assessment of multi-nutrient herbal tablets.

Keywords

Multi-nutrient herbal tablet Tulsi, Cinnamon, Clove, Ginger, Thickness, Hardness, Weight variation, Friability, Wet granulation

Introduction

Nutrition, the study of food and its impact on health, is essential for disease prevention and overall well-being. The significance of a healthy diet in maintaining good health has been acknowledged since ancient times. In modern society, with the increase in chronic diseases and lifestyle-related health issues, the need for a balanced diet rich in vital nutrients is more evident than ever.The use of herbal supplements for health promotion and dietary support has gained popularity due to their believed therapeutic effects and minimal side effects.Herbs like amla (Indian gooseberry), tulsi (holy basil), cinnamon, licorice, mint, and ginger are highly valued for their nutritional and healing properties. These plants have been revered across various cultures for their health benefits, such as immune-boosting, digestive aid, and antioxidant effects. Research into the formulation and evaluation of herbal products, particularly tablets for easy consumption, has significantly increased due to the growing demand for natural remedies1.  Combining multiple herbal ingredients into a single multi-nutrient tablet offers a promising approach to enhance overall health and well-being. This study aims to examine the preparation and evaluation of a multi-nutrient herbal tablet containing ginger, mint, amla, tulsi, cinnamon, and licorice. These botanicals are transformed into a unified tablet using the effective wet granulation method, ensuring consistency and potency in the final product. The study focuses on evaluating key factors that influence the tablet's effectiveness and quality, such as weight variation, hardness, thickness, and friability, which are crucial for its stability, efficacy, and consumer acceptance. This research contributes to the growing field of herbal medicine and nutraceuticals by exploring the formulation process and establishing quality standards for the tablet. The findings suggest potential for developing multi-nutrient herbal supplements that provide a natural, holistic approach to maintaining health and preventing disease. The concept of using food for health benefits beyond basic nutrition is gaining traction in both public and scientific circles2. Nutraceuticals—natural compounds extracted or purified from food—are believed to offer physiological benefits and prevent chronic diseases. The term was coined by

Dr. Stephen L. De Felice, founder of the Foundation for Innovation in Medicine. Nutraceuticals, often referred to as "functional foods," have sparked debate due to their blurred lines between food and medicine3.

With growing public demand and favorable demographic and socioeconomic trends, research indicates that nearly two-thirds of the world’s population uses plant-based remedies for reasons such as accessibility, safety, cost, and cultural tradition. The health benefits of food have been studied for thousands of years.

The reasons for shift towards nutraceuticals are:

  1. An increasing number of consumers, worried about rising healthcare expenses.
  2. Frustrated with the effectiveness of pharmaceutical agents in promoting health, are turning to nutraceuticals for better health and disease prevention.
  3. Healthcare providers acknowledge that our heavily processed food, grown with chemical fertilizers, pesticides, herbicides, and often genetically modified seeds, lacks the essential nutrients needed for optimal health.
  4. A growing belief in prevention over treatment.
  5. Individuals with chronic illnesses who have found no relief from conventional medicine.
  6. Patients facing economic challenge4.

 Herbs used in our research:

  1. Tulsi (Ocimum sanctum)

Reference

  1. Rose ME, Herbin MB, Melick J, Marion DW, Palmer AM, Chiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6.
  2. Kalra, E. K. (2003). Nutraceutical—Definition and introduction. AAPS Pharm Sci Tech, 5(3), 27-28.
  3. Dillard, C. J., & German, J. B. (2000). Phytochemicals: Nutraceuticals and human health. Journal of the Science of Food and Agriculture, 80(12), 1744-1756.
  4. Sathish Kumar, R., & Priya, M. (2014). Phylogenetic analysis of Ocimum species: A molecular approach. Journal of Medicinal Plant Research, 8(11), 406-412.
  5. Jayaprakasha, G.K., Rao, L.J.M., & Sakariah, K.K. "Chemical composition of volatile oil from Cinnamomum zeylanicum buds." Journal of Agricultural and Food Chemistry, 2001, 5392–5393
  6. Ghasemzadeh, A., & Jaafar, H. Z. E. (2011). Profiling of phytochemical compounds and their antioxidant and anticancer activities in different varieties of young ginger (Zingiber officinale Roscoe). International Journal of Molecular Sciences, 12(11), 6608–6623
  7. Marx, W., Ried, K., McCarthy, A. L., Vitetta, L., Sali, A., & Isenring, E. (2017). Ginger—Mechanism of Action in Chemotherapy-induced Nausea and Vomiting: A Review. Critical Reviews in Food Science and Nutrition, 57(1), 141–146.
  8. Banerjee, S. et al. (2006). “Clove (Syzygium aromaticum) extract has anti-proliferative and pro-apoptotic effects on cancer cells.” Journal of Medicinal Food, 9(4), 520–526.
  9. Practical Pharmacognosy: Techniques and Experiments Khandelwal, K. R. Edition:19th edition, Nirali Prakashan, 2008: 149–155
  10. Wallis, T.E. Textbook of Pharmacognosy. 5th ed., CBS Publishers & Distributors, 2005, Page 126-128
  11. Aulton, M.E. Aulton's Pharmaceutics: The Design and Manufacture of Medicines. 4th ed., Churchill Livingstone, 2013.Page 582-583
  12. Lachman, L., Lieberman, H.A., & Kanig, J.L. The Theory and Practice of Industrial Pharmacy. 3rd ed., Varghese Publishing House, 1987. Page 293-295
  13. Allen, L.V., Popovich, N.G., & Ansel, H.C. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 10th ed., Wolters Kluwer, 2014. Page 209
  14. Shargel, L., & Yu, A.B.C. Applied Biopharmaceutics & Pharmacokinetics. 7th ed., McGraw-Hill Education, 2016. Page 532
  15. United States Pharmacopeia (USP 43 – NF 38). United States Pharmacopeial Convention, 2020 General Chapter <711> – Dissolution, pages 321–325
  16. Banker, G. S., & Rhodes, C. T. (Eds.). (2002). Modern Pharmaceutics (4th ed.). CRC Press Chapter on "Granulation and Tablet Formation" (pp. 175-210) will provide detailed methods for tablet compression and granulation.
  17. Benzie, I. F. F., & Wachtel-Galor, S. (Eds.). (2011). Herbal Medicine: Biomolecular and Clinical Aspects. CRC Press/Taylor & Francis Chapter 10: Herbal Dosage Forms (pp. 238-260).

Photo
Sanskar Biradar
Corresponding author

Research Scholar, Department of Pharmacognosy, Late Narayandas Bhawandas Chhabada Institute of Pharmacy, Raigaon, Satara. Dist: Satara, Maharashtra. 415020

Photo
Tushar Gaikwad
Co-author

Assistant Professor, Department of Pharmacology, Late Narayandas Bhawandas Chhabada Institute of Pharmacy, Raigaon, Satara. Dist: Satara, Maharashtra. 415020

Sanskar Biradar*, Tushar Gaikwad, Formulation and Evaluation of Multi Nutrition Herbal Tablet, Int. J. Sci. R. Tech., 2025, 2 (4), 244-249. https://doi.org/10.5281/zenodo.15199306

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