Gurav Siddhi *
Khamkar S. P.
Fungal infections are mainly common infection in the natural world. In humans, the fungal infections occur when a fungus takes over an area of the body and hence it is difficult to handle by immune system. There are many fungi like helpful fungi and harmful fungi, harmful fungi invade the body, they can be very difficult to kill and re-infect the person trying to get the better and they can also survive in the desired environment. Fungal infections are mainly common in humans and also usually not a serious issue if they are treated very quickly and correctly. With a weakened immune system, anyone can be more likely to contact a fungal infection, as well as anyone who is taking the antibiotics. The cancer treatment and diabetes can may also make a person more suffer to the fungal infections. [1] Literature is an enriched source with several reports which prove that the plants act as a potential source of the bioactive secondary metabolites. Azadirachta indica, commonly known as neem and nimtree, it belongs to the family of Meliaceae. In the genus Azadirachta, it is the one of two species and is easily available all over the world like India, Nepal, Maldives, Sri Lanka, Bangladesh etc. A. indica has been easily grown in the semi-tropical and also the tropical regions and also shows many activities like antifungal, antiviral, antibacterial, contraceptive, antiproliferative, antioxidant etc. Its main constituents are applied in alternative Ayurveda, Unani, Homeopathy and modern medicinal system. e.g. mainly for the treatment of infections, cancer diseases etc. So, the evergreen neem shows many activities and also various useful medicinal uses. [2] Nelumbo nucifera, is also known as Indian lotus, sacred lotus and American lotus, is an aquatic plant that belongs to the family of Nelumbonaceae. Reomerine is a main chemical constituent present in the leaves of N. nucifera and is also responsible for the antifungal activity of leaf of this plant. More than 400 years before, it has also been recorded in the most famous medicinal book in china. It mainly shows many of the bioactivities including antioxidant, anticancer and antimicrobial. Leaves, seeds, flower, rhizome and other part of this plant are mainly useful in the traditional system of medicine. Fungal infections are also common among all people of all age groups and development of new natural and safe therapeutic antifungal topical preparation is the plan of our study. The major aim of the present study was to investigate the antifungal activity of methanolic and ethanolic extract of Nelumbo nucifera and Azadirachta indica and hence to formulate a natural, safe antifungal cream that contains the combination of both the extract and to evaluate mainly its physicochemical properties. [3]
OBJECTIVES:
1] Demonstrating the leaf extracts of Nelumbo nucifera and Azadirachta indica that possess significant antifungal properties against the common fungal pathogens like Candida albicans.
2] Determining mainly the optimal extraction methods and concentrations for the desired extracts to maximize their antifungal potency.
3] Developing a cream formulation that helps in incorporating the active plant extracts, mainly focusing on ensuring their stability and bioavailability.
4] Evaluation of the physicochemical properties of the cream including the pH, spreadability, and texture, to ensure its suitability for topical application.
5] Conducting the in vitro and in vivo studies that help to assess the cream's antifungal activity and safety, including testing for irritation and also the sensitization.
6] Comparison of the efficacy of the herbal cream with the standard antifungal formulations.
7] Investigating if combining Nelumbo nucifera and Azadirachta indica extracts in the cream may leads to synergistic antifungal effects, enhancing its overall efficacy. [4]
DRUG PROFILE:
1] Nelumbo Nucifera [Lotus]:
10.5281/zenodo.15401169