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Abstract

"An ultra-thin film containing an active ingredient that dissolves or disintegrates in the saliva at aremarkably fast rate, within few seconds without the aid of water or chewing," is the definition ofa fast-dissolving oral film (FDOF). The most up-to-date oral solid dosage form is fast-dissolving oral films (FDOFs), which provide more comfort and flexibility. It improves the absorption of active pharmaceutical ingredients (APIs) by dissolving them in saliva and allowing them to be swallowed without chewing or water. The oral mucosa is four to a thousand times more permeable than the epidermis, allowing for rapid drug absorption and rapid bioavailability. Formulated drug- opening foams (FDOFs) are made from hydrophilic polymers that dissolve rapidly in the mouth and release the medication into the bloodstream via the buccal mucosa. [1] A fast-dissolving drug delivery method is developed to enhance bioavailability of drugs with modest dosages and significant first-pass metabolism.

Keywords

Fast Dissolving Film, Lisinopril, FDOF, APIs

Introduction

1.2 Oral Dissolving Film Theory:

In this setup, a thin film is present. Sublingual administration improves bioavailability because the drug dissolves faster and bypasses first-pass metabolism. Because SA is more easily absorbed, it breaks down and dissolves rapidly in the mouth. The following are the three main types of oral films:

1. Films have a rapid dissolving or releasing time (when held to the mouth).

2. Mucoadhesive films that dissolve (for use in the buccal or gingival area). The third option is buccal mucosa-adhering sustained-release films. [3]

1.3 Mechanism of oral mouth dissolving film theory:

Reference

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Siddhesh Gawari
Corresponding author

Loknete Shri Dada patil pharate College of pharmacy

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S. R. Ghodake
Co-author

Loknete Shri Dada patil pharate College of pharmacy

Siddhesh Gawari*, S. R. Ghodake, Formulation and Evaluation of Fast Dissolving Film of Lisinopril, Int. J. Sci. R. Tech., 2025, 2 (4), 664-689. https://doi.org/10.5281/zenodo.15304422

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