Abstract
The main objective of this work is the formulation and development of herbal products such as dental gel of clove oil for the treatment of periodontal disease. Periodontal disease is recognized as a one of major public health problem throughout the world and occurs in all groups, ethnicities, races, genders and socio-economic levels. The active ingredient of this dental gel is clove oil. The clove oil was evaluated for physical parameters like acid value, ester value, saponification value and specific gravity. The prepared gel was evaluated for various properties such as antimicrobial activity, pH, spread ability, extrudability, drug content etc. In-Vitro experiments demonstrated that the formulation F3 is a suitable dosage form for the treatment of periodontitis. Clove oil showed the zone of inhibition of about 22.05±0.04 mm. On the basis of the result obtained in this present study we conclude that the gel formulations of clove oil F3 showed good physicochemical properties as well as good drug content compared to other formulations.
Keywords
Clove oil, Carbopol 934, Periodontitis, Anti-microbial activity ,Anti-inflammatory agent , Eugenol ,Gingivitis Treatment, Dental gel, Essential oil formulation , Syzygium aromaticum,Herbal dental gel, Phytotherapy in dentistry, Natural antimicrobial,Gum inflammation,Plaque-induced diseases, Periodontal pocket reduction, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Petrella intermedia, Oral microbiome, Gram-negative anaerobes Oral pathogenic bacteriaGingival healing, Pain reduction, Local drug delivery, Non-surgical periodontal therapy, Adjunctive periodontal treatment
Introduction
Periodontal disease is recognized as a major public health problem throughout the world and occurs in all groups, ethnicities, races, genders, and socioeconomic levels. It is characterized by inflammation and degeneration of the gums, supporting bone, periodontal ligament and cementum and accumulation of bacterial pathogens, mainly within the periodontal pockets the periodontal disease commonly refers to inflammatory diseases that are plaque induced i.e. gingivitis and periodontitis. Gingivitis, the moderate stage of disease caused by an accumulation of supragingival plaque and characterized by swelling. Light bleeding and redness of the marginal gingival. Gingivitis is associated with a change in the microflora, shifting from a Gram-positive anaerobic flora to a more Gram negative one. Periodontitis, a more severe stage of periodontal disease, result in the resorption of the alveolar bone and detachment of periodontal ligament supporting tooth Recent advances in the field of dentistry have promoted the use of herbal and natural products for the treatment of various oral diseases. The conventional method of treatment the periodontal disease like oral, topical, and systemic dosage forms have major disadvantages like superinfection, low or non-compliance, low gingival crevicular fluid levels of antibiotics, systemic side effects, short duration, and high relative cost Clove oil is one such product exhibiting multiple benefits and has gained considerable importance in clinical research Since clove oil shows low intrinsic toxicity along with a wide spectrum of biological actions like analgesic, antiseptic, antispasmodic, anti-neuralgic, carminative, anti-infectious, disinfectant, insecticide, stimulant, stomachic and other useful properties, it is very useful in dentistry also The present study was aimed to formulate dental gel containing clove oil for the treatment of periodontal diseases and then evaluated for their physicochemical properties including drug content, spread ability, extrude ability and in-vitro antibacterial activity. Medicinal plants have been used as traditional treatments for numerous human diseases for thousands of years and in many parts of the world. In rural areas of the developing countries, they continue to be used as the primary source of medicine.
Benefits of Clove Oil:
? Clove oil numbs the tooth and gives quick relief from toothache.
? It has strong germ-killing power, which helps keep the mouth clean.
? Helps decrease redness, swelling, and bleeding of gums.
? Small cuts or sores in the mouth heal faster because it fights infection.
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Sana Sultana Nadaf
Corresponding author
Delight College of Pharmacy Koregaon Bhima Pune,412216
Mayuri Auti
Co-author
Delight College of Pharmacy Koregaon Bhima Pune,412216
Sana Sultana Nadaf*, Mayuri Auti, Review on: - Formulation & Evaluation of Dental Gel Containing Clove Oil for the Treatment of Periodontal Disease, Int. J. Sci. R. Tech., 2025, 2 (12), 322-332. https://doi.org/10.5281/zenodo.17991274
10.5281/zenodo.17991274
