We use cookies to ensure our website works properly and to personalise your experience. Cookies policy
Jagdamba Education Society’s S.N.D. College of Pharmacy, Nashik, Maharashtra, Indi
Losartan, the first angiotensin II receptor blocker (ARB) introduced for clinical use, has become a cornerstone therapy for hypertension, heart failure, and diabetic nephropathy. Its mechanism of action?selective blockade of angiotensin II type 1 (AT1) receptors?offers hemodynamic and renal protection with fewer side effects compared to angiotensin-converting enzyme inhibitors (ACEIs). Despite its favorable efficacy profile, Losartan is associated with adverse drug reactions (ADRs) ranging from mild dizziness and fatigue to rare but life-threatening events such as hyperkalemia, renal dysfunction, and angioedema. Given the widespread and long-term use of ARBs in diverse populations, pharmacovigilance plays a pivotal role in identifying, monitoring, and preventing ADRs. This review consolidates evidence from clinical trials, case studies, and pharmacovigilance databases, highlighting the safety concerns of Losartan, the need for ADR monitoring, and the responsibilities of healthcare professionals and patients in ensuring rational drug use.
Huzaifa Patel*, Maaz Aaquil, Parth Khandelwal, Sohail Shaikh, Nishant Gite, Appa Saheb B. Kuhile, A Review on: - Losartan in Hypertension and Heart Failure: Pharmacovigilance and Adverse Drug Monitoring, Int. J. Sci. R. Tech., 2025, 2 (11), 310-314. https://doi.org/10.5281/zenodo.17577778
10.5281/zenodo.17577778