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Department of Pharmacy- KBHSS Trust’s Institute of Pharmacy, Malegaon, Nashik, Maharashtra- 423203
A chronic inflammatory skin condition, psoriasis affects millions of individuals globally. Natural remedies for psoriasis have drawn attention because of its capacity to lower inflammation and alter the immune system. Psoriasis can potentially be treated using natural compounds derived from traditional Indian medicinal plants.There may be overt signs, including increased plaques, which can seem different depending on the skin type. This condition may result in inflammation of the knees, scalp, lower back, elbows, or other body parts.Many synthetic medicinal drugs have been linked to psoriasis as an undesirable consequence. Herbal medications may be effective in treating psoriasis due to their safety and availability.Skin hyperplasia includes vascular hyperplasia, epidermal keratinocytes, and penetration of neutrophils, leucocytes, and extra types of T lymphocytes in affected areas.The disease has a complex pathogenesis that involves both cellular and genetic components. Because of this, there are numerous therapeutic modalities that target diverse targets, ranging from immune system regulation to symptomatic treatment. Although the exact etiology of the illness is unknown, drugs are known to induce it. Seasonal variations, illnesses, and smoking are examples of environmental factors that are also to blame. Because of the detrimental impacts on life quality and risky side effects of conventional treatment, people are looking for natural alternatives. Many herbs have been used in traditional psoriasis treatment techniques, however there may be safer alternatives.The purpose of this review is to choose these plants for further investigation in order to find the chemical components that combat psoriasis and ascertain their mechanism of action.
Psoriasis is an autoimmune skin disease that is inflammatory and proliferative, resulting from T-cell activation. It is identified by distinctly peach-pink or drab-red hard silvery scale patches that are abrasive to the skin. Hyperkeratosis, dilated microvessels, abnormal keratinization, epidermal proliferation, and inflammatory cell infiltration are further symptoms. A chronic inflammatory dermatosis, psoriasis affects approximately 2% of people. It typically manifests for the first time between the ages of 15 and 30. Brownish-red papules and plaques that are well-defined and covered in tiny, silvery white scales are the lesions’ defining feature. Auspitz signs are tiny bleeding spots that occur when the scales are gently scraped off. Extensor surfaces of the extremities, particularly the knees and elbows, the scalp, upper back, and sacral area are frequently affected. An unusual pitting of the nails is observed in around 25% of patients. About 5% of people get psoriatic arthritis that resembles rheumatoid arthritis, although there is no rheumatoid component.
History of Disease: Greek, Roman, and Arabic literatures, as well as Egyptian literature, contain the first known works about skin illnesses. Skin disorders primarily fell under general medicine in the 16th-century BC Ebers Papyrus. Though cosmetics were a priority at the time, the researchers’ main focus was on ways to stop itching. The names given to different skin conditions weren’t always appropriate, which frequently caused misunderstanding later on. Although leprosy was frequently referenced in the Bible, more research revealed that the disease was typically psoriasis; additionally, examinations of ancient Egyptian mummies revealed no evidence of leprosy (McCaw 1944). According to Gruber et al. (2004), the Bible mentions a condition called “zaraath” that appears to be either psoriasis or leprosy. Although it was initially believed that Moses and his sister Miriam may have had leprosy, additional research revealed that the cutaneous lesions they displayed were more likely to be caused by psoriasis or a fungal infection (liddell 2006). However, seborrheic dermatitis was actually what Galen referred to as psoriasis (Baker 2008). The Greeks used the term “psora” to refer to two conditions: simply psora, which is represented by squamous-crusted lesions, and ulcerated psora, which is characterized by pustular lesions that cause ulceration and is thought to be contagious (Willan 1809).
Manjusha Deore*, Komal Ahire, Yash Jadhav, Kailas Bhoye, Shradha Vaishnav, Ayurvedic Remedies for Psoriasis, Int. J. Sci. R. Tech., 2025, 2 (7), 118-127. https://doi.org/10.5281/zenodo.15817616
10.5281/zenodo.15817616