A growing number of product categories are seeing a trend towards cosmetics based on nanoparticles. Numerous local and international firms are using nanotechnology as a creative way to provide high-quality and effective cosmetic goods. Cosmeceuticals, which are defined as cosmetic products with drug-like properties and whose use has increased over time, are the newest and fastest-growing sector of the health care business. Within the field of cosmeceuticals, nanotechnology has significant importance. Nanotechnology-based cosmetics provide a number of benefits, including increased medication absorption and extended cosmetic effects. This overview describes the several types of nanocarriers used in cosmetics, the products based on nanotechnology that are now available in the market, and current developments in nanotechnology.
Cosmeceuticals, Nanocarriers, Nanoparticles, Skin delivery systems, Cosmetic nanotechnology
The field of technology known as nanotechnology is concerned with the creation of structures that are shorter than 100 nm [1]. It is the process of working with matter at the atomic or molecular level in at least one dimension, with sizes ranging from 1 to 100 nm. Because it covers fields like organic chemistry, surface science, molecular biology, etc., applied science is extraordinarily wide [2][3]. Nanotechnology aids in the cellular level reversal of ageing. To protect the skin from the damaging effects of sunshine, cosmetics are now formulated with nanotechnology. Many forms of nanomaterials and nanocarriers, such as liposomes, niosomes, solid lipid nanoparticles (SLN), nanospheres, nanoemulsions, gold nanoparticles, dendrimers, etc., are utilised in cosmetics. Products used to enhance the appearance of the skin are called cosmetics [4]. The external preparation that is applied to the body's exterior is known as cosmetics [5][6]. "Particles intended to be applied onto human bodies or any part thereof for cleansing, beautifying, promoting attractiveness, or altering the appearance" is how the Food and Drug Administration (FDA) defines cosmetics (U. S. Food, and Drug Administration, 2018) [7]. These days, makeup is seen as a necessary component of life. They contribute to the physiological effect in addition to drawing people towards it. It has received a lot of attention from both men and women throughout the past two to four decades [8]. Cream and powder cosmetics are the most often used types. A cosmetic product with potential therapeutic or drug-like properties is called a cosmetic [9]. It can be chemically synthesised or obtained naturally. In the 1990s, the terms "cosmeceuticals" and "pharmaceuticals" were combined [10].
Two categories exist for nanoparticles:
- The nanosphere
- Little capsules
Reference
- A.D. Maynard, Nanotechnology: A Research Strategy For Addressing Risk, PEN,2006
- Robert, F.S. (2005). EPA ponder voluntary Nanotechnology Regulations. Science 309: 36.
- Taylor and Francis (2007) “A Handbook on Nanoscience, Engineering and Technology” 2nd Edition
- A. Gautam and R. Singh Vijayaraghavan, “Dermal Exposure of Nanoparticles: an understanding,” Journal of Cell and Tissue Research, vol.11, no.1, page no.2703-2708, 2011
- S. Mukta and F.Adam, “ Cosmeceuticals in day to day clinical Practice,” Journal of Drugs in Dermatology, Vol.9, page no. 62-69, 2010
- Millikan LE (2001). Cosmetology, cosmetics, cosmeceuticals: Definition and regulations. Clinical Dermatology. 19(4): 371-374
- U.S Food and Drug Administration, “Is it a cosmetic, a drug, or both? (or is it soap?),” http://www.fda.gov/cosmetics/guidancecomplianceregulatoryinformation/ucm074201.htm.
- Sharma K Gaurav, Gadiya Jayesh and Dhanawat Meenakshi “Textbook of Cosmetic Formulations”. Page no. 3
- Choi CM, Berson DS(2006). Cosmeceuticals, Semin. Cutan. Med. Surg. 25(3): page no. 163-168
- Dooley, T.P. 1997. “Drug Discovery Approaches for Developing Cosmeceuticals”. Advanced skin care and cosmetics Products. Southborough: IBC Library Series
- B. Mamo, “Literature review on Biodegradable Nanospheres for Oral and Targeted Drug Delivery,” Asian Journal of Biomedical and Pharmaceutical Sciences, vol. 05, no. 51, pp. 01–12, 2015.View at: Publisher Site | Google Scholar
- Benita. S. 1998. Microparticulate drug delivery systems: release kinetic models. Microspheres, Microcapsules and Liposomes (the MML Series). R. Arshady (Ed.), Citrus Books, London, pp. 255- 278.
- Reva T, Vaseem AA, Satyprakash S, Md. Khalid JA. Liposomes: The Novel Approach in Cosmeceuticals, World J Pharm Science 2015: 4(6): 1616-40
- Scholtz JC. Liposomes as Drug Delivery System. 2010
- Nastruzzi C, EspositoE, Walde P,“Stability of Liposomes in Dermatological Preparations”. J Appl Cosmetol.1993: 77-91
- Vinardell MP, Mitjans M. Nanocarriers for delivery of antioxidants on the skin. Cosmetics. 2015, 342-354
- Lohani A, Verma A, Joshi H, Yadav N, Karki N” “Nanotechnology based Cosmeceuticals” ISRN Dermatol 2014
- S. Duarah, K.Pujari, R.D. Durai, and V.H.B. Narayanan“Nanotechnology Based Cosmeceuticals” A review International Journal of applied Pharmaceutics,vol. 8, no. 1, pp8-12,2016.
- A.Gandhi, A. Paul, “ Current Trends in Niosomes as Vesicular Drug delivery System”. Asian Journal of Pharmacy and Life Science, vol.2. pp. 339,2012
- Tomalia DA, Baker H, Dewald JR, Kallos G, Martin S, Roeck J, Smith P.A new class of polymers: Starbust- dendritic macromolecule. Polym. J. 1985,17, 117-132
- F. Vogtle E, WeberA. Chem.Int. Ed. Engl,1974, 13, 814-815
- Newkome GR, Yao ZQ, Baker GR, Gupta VK. Cascade Molecule: A New Approach to Micelles. J. Org. Chem.1985,50.
- Rainer H. Muller, Karsten Mader and Sven Gohlaa, Eur. J. Pharm. Biopharm., 50(1), 161-177(2000)
- Melike Uner, gulgun Yener, Int. J. Nanomedicine, 2(3), 289-300(2007)
- S. Mukherjee, S. Ray and R.S Thakur, Ind. J. Pharm. Sci., 349-358(2009)
- Wolfgang Mehnartband Karsten Mader, Adv. Drug. Delivery., Rev., 47, 165-196 (2001)
- Rainer H. Muller, Karsten Mader and Sven Gohlaa, Eur. J. Pharm. Biopharm., 50(1), 161-177(2000).
- Houli Li, Xiaobin Zhao, Yukun Ma and Guangxi Zhai, Ling Bing Li and Hong Xiang, Lou. J. Cont. Release, 133, 238-244(2009).
- Melike Uner, gulgun Yener, Int. J. Nanomedicine, 2(3), 289-300(2007).
- K. Lata, K.J. Arvind, N. Laxmana, and S. Rajan, “Gold Nanoparticles: Prepartion, Characterization and its stability in buffer,” A Journal of Nanotechnology and its application, Vol.17, 1-10, (2014).
- A.K. Khan, R. Rashid, G. Murtaza, and A. Zahra, “Gold Nanoparticles: Synthesis and application in drug delivery,” Tropical Journal of Pharmaceutical Research, vol13, no.7, 1169-1177,(2014).
- A.S Thakor, J. Jokerst, C. Zavaleta, T.F. Massoud, and S.s. Gambhir, “Gold Nanoparticles: a revival in precious metal administration to patients,” Nanoletters, Vol11, 4029- 4036, (2001).
- M. Ambikanandan, Challenges in Delivery of Therapeutic Genomics and Proteomics, Elsevier, 2011.
- S.-H. Kim,H. C. Shum, J. W. Kim, J.-C. Cho, and D. A. Weitz, “Multiple polymersomes for programmed release of multiple components,” Journal of the American Chemical Society, vol. 133, no. 38, pp. 15165–15171, 2011.View at: Publisher Site | Google Scholar
- D. E. Discher and A. Eisenberg, “Polymer vesicles,” Science, vol. 297, no. 5583, pp. 967–973, 2002.View at: Publisher Site | Google Scholar
- H. Bermudez, A. K. Brannan, D. A. Hammer, F. S. Bates, and D. E. Discher, “Molecular weight dependence of polymersome membrane structure, elasticity, and stability,” Macromolecules, vol. 35, no. 21, pp. 8203–8208, 2002.View at: Publisher Site | Google Scholar
- https://patents.google.com/patent/US20130171274.
- https://patents.google.com/patent/KR101659314B1/en.
- P. Shah, D. Bhalodia, and P. Shelat, “Nanoemulsion: A pharmaceutical review,” Systematic Reviews in Pharmacy, vol. 1, no. 1, pp.24–32, 2010.View at: Publisher Site | Google Scholar
- P. P. Ronak and R. J. Jay,“An overview on nanoemulsion: a novel approach,” International Journal of Pharmaceutical Sciences and Research, vol. 3, no. 12, pp. 4640–4650, 2012.View at: Google Scholar
- S. Ozgun, “Nanoemulsions in cosmetics,” Nanomaterials and Nanotechnology.View at: Google Scholar
- June IM, Davange RM, Salunkhe KS, Chaudhari SR, Deshmukh PD, et al. (2016) Nanostructured lipid carrier: Novel drug delivery system. J Adv Drug Deliv 3: 7-16.
- Xia Q, Wang H (2010) Preparation and characterization of coenzymes Q-10 loaded NLC. NSTI-Nanotech 3: 498-501.
- Shah R, Eldridge D, Palombo E, Harding I (2015) Lipid Nanoparticles: Production, Characterization and Stability. Briefs Pharm Sci Drug Dev 1: 11-23.
- Jaiswal P, Gidwani B, Vyas A (2016) Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol 44: 1-14.
- Radtke M, Müller RH (1991) Nanostructured Lipid Carriers: A novel generation of solid lipid drug drug Carriers. Pharmaceutical Technology Europe 17: 1-4.
- Freund, R.M.2010.A More Beauitful You: Reverse Aging Through Skin Care,Plastic surgery and Lifestyle Solutions.New York Publishing Co.Inc
- T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,” Nanotechnology, Science and Applications, vol. 4, no. 1, pp. 95–112, 2011.View at: Google Scholar
- D. A. Glaser, “Anti-aging products and cosmeceuticals,” Facial Plastic Surgery Clinics of North America, vol. 12, no. 3, pp. 363– 372, 2004.View at: Publisher Site | Google Scholar
- Middleton, J.1974.” Development of a skin cream designed to reduce dry and flaky skin,”J. Soc. Cosmet.Chem.,25(8),pp. 519-534
- Loden, M.2005. “Moisturizers” in P. Elsner and H.I. Maibach(eds.) Cosmeceuticals and Active Ingredients: Drugs versus Cosmetics, Cosmetics Science and Technology Series. Boca Raton: Taylor and Francis.
- Madnani,N. And K. Khan.2013. “Hair Cosmetics.” Indian J.Dermatol., Venereol and Leprol.,79(5), pp. 654-667
- J. Rosen, A. Landriscina, and A. Friedman, “Nanotechnology-Based Cosmetics for Hair Care,” Cosmetics, vol. 2, no. 4, pp. 211– 224, 2015.View at: Publisher Site | Google Scholar
- P. J. L. Viladot, G. R. Delgado, and B. A. Fernandez, “Lipid nanoparticle capsules.,” European Patent 2549977A2, January 2013.View at: Google Scholar
- Sesderma fillderma lips lip volumizer, https://www.dermacaredirect.co.uk/sesderma-fillderma-lip.html.
- "The History of Chapstick - The History of Carmex". About.com. Retrieved 2010-06-30.
- H. Bethany, “Zapping nanoparticles into nail polish,” Laser Ablation Method Makes Cosmetic and Biomedical Coatings in a Flash, vol. 95, no. 12, p. 9, 2017.View at: Google Scholar
- Nano Labs, http://nanolabs.us/press-releases/green-chemistry-and-new-thinking-at-playas-nano-labs-ctle-receives-provisional- patent-for-unique-nanotech-nail-polish/.
- K. Ertel, “Personal cleansing products: properties and use,” in Cosmetic Formulation of Skin Care Products, Z. D. Draelos and L. Thaman, Eds., pp. 32–36, Taylor & Francis, New York, NY, USA, 2006.View at: Google Scholar
- Lambers H, Piessens S, Bloem A, Pronk H, Finkel P (October 2006). International Journal of Cosmetic Science. 28 (5), pp. 359–370
- Calster GV, Bowman DM. Regulatory Design for New Technologies: Spaghetti Junction or Bauhaus Principles for Regulating Innovative Cosmetic Products. 2009; XXV, 94:75-93
- U.S Food and drug Administration,” Import Alert 66-38”, http://www.access data.fda.gov/cms_ia/importalert_188.html.
- “Nanomaterials and the EU Cosmetics Regulation: Implications for Your Company,”
- http://www.gcimagazine.com/business/management/regulation/143553126.html?pa.View at: Google Scholar.
- B. M. Sandoval, Perspectives on FDA's Regulation of Nanotechnology: Emerging Challenges and Potential Solutions, vol. 8, Institute of Food Technologist, 4 edition, 2009.
Kartik More
Corresponding author
Department of Pharmacy, KBHSS Trust’s Institute of Pharmacy, Malegaon -423105, Dist. Nashik, Maharashtra
Chetan Sonje
Co-author
Department of Pharmacy, KBHSS Trust’s Institute of Pharmacy, Malegaon -423105, Dist. Nashik, Maharashtra
Janhavi Shillak
Co-author
Department of Pharmacy, KBHSS Trust’s Institute of Pharmacy, Malegaon -423105, Dist. Nashik, Maharashtra
Sakshi Pawar
Co-author
Department of Pharmacy, KBHSS Trust’s Institute of Pharmacy, Malegaon -423105, Dist. Nashik, Maharashtra
Neha Sonawane
Co-author
Department of Pharmacy, KBHSS Trust’s Institute of Pharmacy, Malegaon -423105, Dist. Nashik, Maharashtra
Shraddha Vaishnav
Co-author
Department of Pharmacy, KBHSS Trust’s Institute of Pharmacy, Malegaon -423105, Dist. Nashik, Maharashtra
Kartik More*, Chetan Sonje, Janhavi Shillak, Sakshi Pawar, Neha Sonawane, Shraddha Vaishnav, The Nanotechnology Revolution in Cosmeceuticals: A Comprehensive Overview, Int. J. Sci. R. Tech., 2025, 2 (6), 447-456. https://doi.org/10.5281/zenodo.15664942
10.5281/zenodo.15664942