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Krishna Foundation Jaywant Institute of Pharmacy Wathar Maharashtra, India
Buccal drug delivery has emerged as a promising alternative to conventional drug administration routes due to its ability to enhance bioavailability and provide rapid onset of action. The buccal mucosa, owing to its rich vascularization and relatively permeable nature, enables efficient transmucosal drug absorption while bypassing hepatic first-pass metabolism. Among various buccal dosage forms, buccal spray formulations have gained significant attention as an innovative and patient-friendly drug delivery system. These formulations allow precise dosing, ease of administration, and improved patient compliance, particularly in pediatric, geriatric, and dysphagic populations. Recent advancements in formulation strategies, including the incorporation of mucoadhesive polymers, permeation enhancers, and nanocarrier systems, have further enhanced the therapeutic efficacy of buccal sprays. Despite these advantages, challenges such as limited absorption surface area, salivary washout, taste masking, and formulation stability remain critical considerations in product development. Furthermore, the design of appropriate spray devices plays a crucial role in ensuring optimal drug deposition and uniform dosing. This review highlights the anatomical and physiological aspects of the buccal mucosa, principles of buccal drug delivery, formulation components, preparation methods, and evaluation parameters specific to buccal sprays. It also discusses current applications, marketed products, recent innovations, and regulatory perspectives. Overall, buccal spray formulations represent a rapidly evolving drug delivery platform with substantial potential to improve therapeutic outcomes and expand the scope of transmucosal drug delivery in modern medicine.
The development of efficient drug delivery systems has become a fundamental aspect of modern pharmaceutical research, aiming to optimize therapeutic efficacy while minimizing adverse effects. Conventional routes of drug administration, particularly oral delivery, remain the most widely utilized due to their convenience and patient acceptance. However, oral drug delivery is often associated with several limitations, including variable gastrointestinal absorption, enzymatic degradation, and extensive hepatic first-pass metabolism, which significantly reduce the bioavailability of many therapeutic agents [1]. These challenges have prompted the exploration of alternative delivery routes, among which transmucosal drug delivery has gained considerable attention. Transmucosal routes, including buccal, sublingual, nasal, and rectal pathways, offer distinct advantages by enabling direct drug absorption into the systemic circulation, thereby bypassing hepatic metabolism and providing rapid onset of action [2]. Among these, the buccal route has emerged as a particularly promising approach due to its accessibility, relatively large surface area, and rich vascularization. The buccal mucosa, lining the inner cheek, provides a favorable environment for drug absorption, characterized by a non-keratinized epithelium and moderate permeability that allows both hydrophilic and lipophilic drugs to permeate under suitable conditions [3]. Buccal drug delivery systems are designed to facilitate the retention of the drug formulation in the buccal cavity for a sufficient duration, enabling controlled and efficient drug absorption. Various dosage forms, such as buccal tablets, films, gels, and patches, have been developed to exploit this route [4]. In recent years, buccal spray formulations have emerged as an innovative and patient-centric dosage form, offering several advantages over traditional systems. These sprays enable rapid drug administration without the need for water, provide accurate dosing, and ensure uniform drug distribution across the buccal mucosa [5]. The growing interest in buccal sprays is driven by advancements in formulation technologies, including the use of mucoadhesive polymers, permeation enhancers, and nanocarrier systems that improve drug residence time and absorption efficiency [6]. Additionally, the integration of sophisticated spray devices has further enhanced the precision and reproducibility of drug delivery. Buccal sprays are particularly beneficial in clinical conditions requiring rapid therapeutic action, such as pain management, cardiovascular emergencies, and central nervous system disorders [7]. Despite their promising potential, buccal spray formulations face several formulation and physiological challenges, including limited drug loading capacity, salivary dilution, and variability in mucosal permeability. Addressing these challenges requires a comprehensive understanding of buccal physiology, drug transport mechanisms, and formulation design principles [8]. Therefore, this review aims to provide a detailed overview of innovative buccal spray formulations, focusing on their design, development, evaluation, and therapeutic applications, along with recent advancements and future perspectives in this rapidly evolving field.
Pranali Jadhav*, Vikram Garale, Adesh Ghanwat, Vaibhav Gunjvate, Sushma Garud, Bhagyesh Janugade, A Comprehensive Review on Design, Development, And Evaluation of Buccal Spray Drug Delivery Systems, Int. J. Sci. R. Tech., 2026, 3 (4), 93-110. https://doi.org/10.5281/zenodo.19393782
10.5281/zenodo.19393782