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Abstract

The aim of this study was to develop and evaluate oral patches containing herbal extracts with antiulcer activity. Four herbal extracts (guava, lavender, thyme and chamomile) were selected based on their traditional use in gastric disorders. The results showed that the buccal patches showed significant anti-ulcer activity, with guava and lavender showing the highest activity. The patch showed faster drug release and better immune response compared to the control group. This study demonstrates the potential of herbs as a novel and effective treatment for oral ulcer.

Keywords

Herbal formulation, Buccal Patches, Ulcer, Anti-ulcer, Guava (Psidium guajava leaves), Lavender (Lavandula angustifolia), Thyme (Thymus vulgaris), Chamomile

Introduction

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Ulcer:

Mouth ulcers, medically known as aphthous ulcers, are diseases of the mucous membranes of the oral cavity. Although they are common and often associated with many conditions, most conditions do not indicate a serious problem. However, persistent, and non-healing disease may be a sign of oral disease. These lesions may appear singly or in groups called "ulcers." Once they form, inflammation and/or secondary infection may cause the sore to become permanent.

Reference

  1. Ankita Saxena; Gulab Tewari; Shubhini Awasthi Saraf Articles • Braz. J. Pharm. Sci. 47 • Dec 2011:
  2. Anu A. L.1, Prasobh G. R.1, Subash Chandran M. P.1, Juno S.1, Subodh S. Satheesh1, Aneesh Kumar A. L.1 and Pooja Nair K. R. from /wjpr20202-16502
  3. Buccal patches: a review IJPSR, 2013; Pradeep Kumar Koyi and Arshad Bashir Khan
  4. R. Venkatalakshmi, Yajaman Sudhakar, Madhuchudana Chetty C., Sasikala C. and Mohan     Varma M. IJPSR, 2012
  5. N Thuille, M Fille, M Nagl, International journal of hygiene and environmental health, 2003
  6. Sabir Shaikh1, Amol Shete2, Rajendra Doijad3 Vol. 6, Issue 4 | magazine.
  7. Noha A Nafee, Fatma A Ismail, Nabila A Boraie, Lobna M Mortada Volume 264, Issues 1–2, 2 October 2003 (Excipients)
  8. E Stahl-Biskup, RP Venskutonis, Handbook of herbs and spices, 2004
  9. Surya N. Ratha Adhikari, Bhabani S. Nayak, Amit K. Nayak, and Biswaranjan Mohanty corresponding author PMC articles.
  10. JK Srivastava, E Shankar, S Gupta, Molecular medicine reports, 2010
  11. Saudi Journal of Biological Sciences Volume 30, Issue 6, June 2023, 103651
  12. JK Srivastava, S Gupta, Journal of agricultural and food chemistry, 2007
  13. K. Chandra Sekhar, K. V. S. Naidu, Y. Vamshi Vishnu, Ramesh Gannu, V. Kishan &Y. Madhusudan Rao published date:10 Oct 2008 https://doi.org/10.1080/10717540801952639
  14. Ankita Saxena; Gulab Tewari; Shubhini Awasthi Saraf Articles • Braz. J. Pharm. Sci. 47 • Dec 2011:
  15. Formulation and Evaluation of Herbal Mouth Ulcer Gel of Guava Leavesp Masatkar, T Bano
  16. Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose S Kumar, KJ HimmelsteinJournal of pharmaceutical sciences, 1995

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Shivraj Mane
Corresponding author

Progressive Education Society’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India- 411044

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Anushka Kamble
Co-author

Progressive Education Society’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India- 411044

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Lochan Khadke
Co-author

Progressive Education Society’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India- 411044

Photo
Shweta Mhetre
Co-author

Progressive Education Society’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India- 411044

Shivraj Mane*, Anushka Kamble, Lochan Khadke, Shweta Mehtre, Herbal Formulation and Evaluation of Buccal Patches Showing Anti-Ulcer Activity, Int. J. Sci. R. Tech., 2025, 2 (3), 495-504. https://doi.org/10.5281/10.5281/zenodo.15090016

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